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Ch. 40 Antivirals Flashcards | StudBud
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Ch. 40 Antivirals
Ch. 40 Antivirals
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1
Valacyclovir (Valtrex)
may cause what adverse effects?
Tremor
Renal failure and GI upset
HA and vertigo
Thromboticthrombocytopenia purpura
2
Maraviroc (Selzentry),
used with other agents to treat HIV-1 and those resistant to other antiretrovirals, is a...
Protease Inhibitor
NTRI
CCR5 Antagonist
HIV Fusion Blocker
3
when giving
Acyclovir (Zovirax)
via IV administration...
Hydrate the patient during the infusion and for 2 hours after
Monitor for dysrhythmias.
Administer by slow IV infusion
Monitor for SOB and wheezing.
4
Acyclovir (Zovirax)
is used to treat...
HIV
GenitalHerpes HSV2
Shinglesand chickenpox HSV 3 or VZV
Coldsores HSV 1
5
Telbivudine (tyzeka)
given for Hepatitis B may cause which adverse effects?
HA, N/V
Renal dysfunction
photosensitivity
Fatigue, myalgia
6
Oseltamivir (Tamiflu) & Oseltamivir (Relenza)
are Neuraminidase Inhibitors indicated for...
RSV
Influenza A
Influenza B
Hepatitis C
7
Remdesivir (veklury)
is FDA approved antiviral treatment for...
ventilated COVID-19 patients only
hospitalized COVID-19 patients only
all COVID-19 patients
CMV
8
nursing implications for
Ganciclovir (Cytovene, Zirgan)
include...
Monitor liver function
Monitor CBC due to bone marrow suppression
May have to reduce dose (dose limiting effect)
Give with food
9
the NTRI
Zidovudine (Retrovir)
has what abbreviations?
(select all that apply)
AZT
RSV
ZDV
CMV
10
advantages of
Valacyclovir (Valtrex)
over Acyclovir (Zovirax) include...
Morepain relief
Less frequent dosing
Can give with nephrotoxic drugs
Renal function not important
11
the NTRI
Zidovudine (Retrovir)...
is used to prevent HIV infection after known exposure
was the first drugavailable to treat HIV
is reserved for HIV that's become resistant to other antiretrovirals
12
Protease Inhibitors...
Block HIV fusion process
Block HIV entry into cell
Inhibit the action of HIV protease
Block activity of reverse transcriptase
13
Ribavirin (Virazole)
indicated for RSV and Hep C acts by...
Interfering with viral replication
Destroying viral cell membranes
Interfering with RNA synthesis
Interfering with DNA synthesis
14
patient teaching for
Oseltamivir (Tamiflu) & Oseltamivir (Relenza)
may include...
Change positions slowly.
Wear sunscreen due to photosensitivity.
Treatment must begin no later than 2 days after onsetof symptoms
Avoid hazardous activity until aware of its effects
15
Non-nucleoside and/or nucleoside reverse transcriptase inhibitors (NNRTI or NRTI)...
Inhibit the action of HIV protease
Block HIV entry into cell
Block HIV fusion process
Block activity of reverse transcriptase
16
Simeprevir (Olysio)
is a Protease Inhibitor indicated for...
Influenza A & B
Hepatitis B
CMV
chronic Hepatitis C
17
a virion is a...
immature virus particle
component of the virus cell membrane
mature virus particle
antiviral drug
18
CD 4 levels indicate HIV is killing the immune cells when they are...
reduced
elevated
19
Sofosbuvir (Solvaldi)
is an RNA Polymerase Inhibitor indicated for...
Hepatitis C
Hepatitis B
20
viruses are difficult to treat because...
Viruses replicate millions of times before symptoms appear
Viruses are untreatable.
We don't know how.
They reproduce inside a host cell; drug must get inside the cell as well
21
normal CD4 levels would be...
(select all that apply)
900
650
400
250
22
nursing implications for the HIV Fusion Blocker
Enfuvirtide (Fuzeon)
include...
(select all that apply)
Monitor for s/sx of a anaphylactic or injection site reaction
Monitor blood lipid levels due to possible hyperlipidemia
Monitor for s/sx of a respiratory infection
Monitor pancreatic enzymes due to possible pancreatitis
23
nursing implications for the NTRI
Zidovudine (Retrovir)
include...
(select all that apply)
Ask about current medications due to the many drug interactions
Monitor pancreatic enzymes due to possible pancreatitis
Monitor blood lipid levels due to possible hyperlipidemia
Monitor liver enzymes
24
Telbivudine (tyzeka) is an antiviral used to treat...
Hepatitis B
Hepatitis C
25
Ganciclovir (Cytovene, Zirgan)
may cause what adverse effects?
Liver dysfunction
Anemia
Reproductive toxicity
Bone marrow suppression
26
the NTRI
Zidovudine (Retrovir)
may cause...
(select all that apply)
CNS reactions; HA, insomnia, peripheral neuropathies, A
pancreatitis
bone marrow suppression
fatty liver
27
what organ function is particularly important when giving
Acyclovir (Zovirax) or Valacyclovir (Valtrex)
?
Cardiac function
Respiratory function
Kidney function
Liver function
28
Valacyclovir (Valtrex)
is used to treat...
Coldsores HSV 1
Shingles - Herpes zoster
Genitalherpes HSV 2
Cytomegalovirus-CMV
29
the HIV Fusion Blocker
Enfuvirtide (Fuzeon)...
is used to prevent HIV infection after known exposure
was the first drugavailable to treat HIV
is reserved for HIV that's become resistant to other antiretrovirals
30
the Protease Inhibitor
Indinavir (Crixivan)
may cause...
(select all that apply)
hyperlipidemia and fat malabsorption
kidney stones
elevated liver enzymes
hyperglycemia
31
Amantadine (Symmetrel)
is not recommended for use by the FDA because of...
its rising resistance
its Black Box Warning
32
Oseltamivir (Tamiflu) & Oseltamivir (Relenza)
may cause which adverse effects?
N/V
Anaphylactic reaction
Hepatotoxicity
Neurotoxicity
33
Sofosbuvir (Solvaldi)
given for Hepatitis C may cause...
rash
fatigue
itching
HA
34
Valacyclovir (Valtrex)
can not be given with...
Food
Nephrotoxic drugs
35
Acyclovir (Zovirax)
may cause what adverse effects?
Seizures
Reversible nephrotoxicity
GI upset
Neurotoxicity
36
Ganciclovir (Cytovene, Zirgan
) acts to suppress viral DNA replication and is indicated for...
Influenza A
COVID-19
Hepatitis C
CytomegalovirusInfection (CMV)
37
the CCR5 Antagonist
Maraviroc (Selzentry)
may cause...
(select all that apply)
hypotension & dizziness
respiratory infections and/or CV events
hepatotoxicity & fever
abdominal and muscle pain
38
Simeprevir (Olysio)...
may exacerbate Heart Failure
may increase someone's chances of sunburn
is used along with interferons
should not be used in pregnancy
39
nursing implications for the CCR5 Antagonist
Maraviroc (Selzentry)
include...
(select all that apply)
Monitor blood lipid levels due to possible hyperlipidemia
Monitor liver enzymes
Ask about current medications due to the many drug interactions
Monitor pancreatic enzymes due to possible pancreatitis
40
Amantadine (Symmetrel) is a Dopamine Modulator indicated for...
Influenza A ***
Hepatitis C
Influenza B
Hepatitis B
41
the HIV Fusion Blocker
Enfuvirtide (Fuzeon)
may cause...
(select all that apply)
hypotension
fever and chills
pneumonia
allergic and injection site reactions
42
HIV...
incorporates itself into a normal cell's RNA
binds to CD4 molecules on T4 helper lymphocytes
has protective coatings making it hard to kill
is a retrovirus which uses reverse transcriptase during replication
43
the Protease Inhibitor
Indinavir (Crixivan)
...
is used to prevent HIV infection after known exposure
was the first drugavailable to treat HIV
is reserved for HIV that's become resistant to other antiretrovirals
44
the goal of all antiretrovirals is to...
have 50 ≤ copies of a virus in the body
reduce transmission of the virus
reduce the viral load
45
Chemokine Receptor 5 (CCR5) Antagonists...
Inhibit the action of HIV protease
Block activity of reverse transcriptase
Block HIV entry into cell
Block HIV fusion process
46
Fusion Inhibitors...
Block HIV fusion process
Block HIV entry into cell
Block activity of reverse transcriptase
Inhibit the action of HIV protease
47
Simeprevir (Olysio)
may cause which adverse effects?
Pruritis
Photosensitivity
Rash
Insomnia
48
nursing implications for the Protease Inhibitor
Indinavir (Crixivan)
include...
(select all that apply)
Monitor liver & kidney function
Monitor blood lipid levels due to possible hyperlipidemia
Monitor blood sugar due to possible hyperglycemia
Monitor pancreatic enzymes due to possible pancreatitis
49
Ribavirin (Virazole)
may cause which adverse effects?
Birth defects when taken during pregnancy
Seizures
Anemia
Neurotoxicity
50
Sofosbuvir (Solvaldi)
given for Hepatitis C is given with an interferon
True
False
51
Ribavirin (Virazole)
is a Nucleoside Analogue indicated for...
Hepatitis C
Influenza A
RSV
Hepatitis B
52
Amantadine (Symmetrel)
given for Influenza A may cause what adverse effects?
Blurred vision
Renal failure
Insomnia
Hypotension and dizziness
