COAG

Heat-labile, activity deteriorates within a few hours

Inherited defect/acquired with liver disease resulting in defective fibrin formation & thrombosis

How long after centrifugation must the plasma be separated from the cells?

A deficiency in factor ______ causes hemophilia A

Factor II: ____________

A blood vessel that is damaged contracting to decrease blood flow

Factor VIII: ____________

Factor III: ____________

Which therapy is best monitored with the aPTT

Coagulation factors are protein in nature, what is the exception?

Factor IV: ____________

Factor XIII: ____________

D-Dimer is a fibrin split product, and is measured through the D-dimer test

___ is the time required for plasma to clot after an excess of thromboplastin & an optimal conc. of calcium are added

In the qualitative D-dimer test, what is a positive result?

CATA: Associated conditions of acquired coagulation disorders include

Factor XI: ________

The best quantitative method to test fibrinogen is comparing patient clotting time to an unknown standard

Coagulation factors are _________ in nature

CATA: Which pathways are measured in the PT?

_____ is a deficiency of factor IX and is a sex-linked, recessive coagulation disorder

Thrombocytopenic Purpura will _____ the bleeding time

Normal values for bleeding time are 2.3-9.5 minutes

CATA: Clinical conditions where clots migrate throughout the body

The Fibrinogen group factors do not require Vit. K for synthesis

VonWillebrand's and Hemophilia A are examples of

________ acts as a catalyst, accelerating the activity of anti-thrombin

If the PT level is increased, what can occur?

The INR was devised so that patients with PT testing in different laboratories would yield comparable results

Inherited condition where fibrinogen levels are decreased

Factor VII: ____________

Factor IX: ___________

Factor I: __________

Platelets release dopamine during vasoconstriction which continues to narrow blood vessels on a long term basis

The complex process where the body stops bleeding and maintains blood in the fluid state within the vascular compartment

Platelet adhesion to exposed collagen within the endothelium of the vessel wall

CATA: Which factors are in the fibrinogen group?

CATA: Reagents for aPTT include:

Platelets come in contact with collagen, platelet aggregation occurs and a clot forms

Point of Care assays are most useful when used in the clinical lab

If the PT level is decreased, what can occur?

What are the 3 groups of factors?

The time required for cessation of bleeding after a standardized capillary puncture to the capillary bed

In the bleeding time test, the BP cuff only needs to be inflated at the beginning, prior to the puncture

The Ivy Bleeding Time method is the method of choice

Factor X: _______

The only difference between the Mielke Modification and the Simplate method, is the lancet dimensions

What is the anticoagulant of choice for coag studies?

Plasminogen is _______

The ratio of anticoagulant to blood is ___

The D-dimer test is diagnostic for DIC

Which therapy is best monitored with the PT/INR

The antibody used to bind D-dimer is polyclonal

CATA: Methods for performing bleeding time

Plasmin splitting apart the fibrin clot describes:

CATA: Criteria for specimen rejection in coag studies

Inherited disorders may only appear in adulthood

Helps to activate thromboplastin and convert prothrombin to thrombin

Physical effect of the surrounding tissues which close and seal the tear in the vessel that is injured.

Which group of factors increases in inflammation, pregnancy, and oral contraceptive use?

Out of control and accentuated coagulation describes

CATA: Automated analyzers are also capable of measuring

The hemostatic mechanism is divided into 3 subgroups. What are they?

At the end of the clotting process, circulating plasminogen is converted to plasmin

Rare inherited recessive trait characterized by a lack of fibrinogen

Plasmin is found in the circulating blood

Abnormality or deficiency of coagulation factors do not have an affect on bleeding time

An inadequate puncture during bleeding time would

Which of the following are accurate steps of the bleeding time test?

Factor XII:__________

Factors that are not found in the blood are within which pathway?

For PT, the laboratory does not need to establish its own reference ranges for each lot of controls

What is the active enzyme responsible for digesting fibrin?

Factor V: ________

A plasma protein found in the liver, and required for the formation of a fibrin clot

CATA: Acquired disorders are characterized by

In automated assays what measures the rate of change of light absorbance; a more reproducible method?

CATA: aPTT testing detects deficiencies within which pathways?

What factors are in the prothrombin group?

Enzymatic activation of coagulation proteins to produce fibrin from fibrinogen.

The contact group contains which factors?

CATA: Reagents used for PT are: