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Cology II exam 1 Flashcards | StudBud
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Cology II exam 1
Cology II exam 1
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Questions
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Answers
1
True or False: Are soft drugs such as hydrocortisone a prodrug?
False
True
2
Which of the following is the correct order for drug discovery and development?
Lead Discovery --> Target Discovery --> Lead Optimization
Target Discovery --> Lead Optimization --> Lead Discovery
Lead Optimization--> Lead Discovery -->Target Discovery
Target Discovery --> Lead Discovery--> Lead Optimization
3
Which of the following ICS maintenance steroids do you predict would have the longest duration of action?
A
BOTH A + B
B
C
4
What is atropines MOA?
Nicotinic agonist
Muscarinic agonist
Nicotinic antagonist
Muscarinic antagonist
5
Which of the following H1 blockers will NOT readily cross the blood brain barrier
B
C
D
A
6
Which of the following molecules does methotrexate mimic?
Folic acid
Inosine
Purines
Pyrimidine
7
Which 2 enzymes are needed for prostaglandin synthesis?
Cox 1&2
Lipox 3&4
Cox 3&4
Lipox 1&2
8
Which of the following is the most selective for the B-2 receptor?
A
D
C
B
9
Which of the following targets JAK inflammatory pathways?
Abatacept
Roflumilast
Tofacitinib
Adalimumab
10
Which of the following ICS maintenance steroids do you predict would have the fastest onset of action?
C
BOTH A + B
B
A
11
Cholinergic responds to ______
Norepinephrine
Acetylcholine
Epinephrine
Dopamine
12
Which of the following additions would enhance activity for gluco and mineralcorticoids at positions 6 and 9?
Methylation
Amination
Halogenation
Hydroxylation
13
Which CADD approach relies on knowledge of other molecules that bind to the biological target of interest?
Compound Based Virtual Screening
Structure Based Virtual Screening
Vector Based Virtual Screening
Ligand Based Virtual Screening
14
Which of the following is false about this compound?
It does not readily cross the blood brain barrier
It’s a 2nd gen H1 blocker
Its exists as a zwitter ion at physiologic pH
It readily crosses the blood brain barrier
15
Which of the following factors contribute to the poor oral bioavailablilty of sirolimus and ridaforolimus?
Water insolubility
Highly CYP substrates
Substrates of PGP
Eliminated in feces or urine
16
Which of the following are part of the most important biochemical families that plants synthesize?(select all that apply
Flavonoids
Alkaloids
Retinoids
Terpenoids
17
Which of the following inhaled B2 agonists will have the longest duration of action?
B
A
C
D
18
Based on the chemical structure which drug class is this in?
TKI
TNF-a inhibitor
JAK/STAT inhibitor
IL-6 Inhibitor
19
Which of the following are Eicosanoids? Select all that apply
Tumor Necrosis Factor
Leukotriene
Thromboxane
Prostaglandin
20
name the behavioral test that evaluates the effect of a lead compound and is involved in this stage of drug discovery
Irwins Test, Lead Optimization
Irwin’s Test, Lead Discovery
Ames Test, Lead Optimization
Ames Test, Lead Discovery
21
Cardiac glycosides were identified from the leaves of the _______
Cinchona tree
Sweet Wormwood
Opium Poppy
Foxglove
22
Which of the following does glucocorticoids target?
Suppression of innate immune cells
Block intracellular signaling
Precent proliferation of lymphocytes
Inhibit gene expression
23
Which of the following is how misoprostol reverses NSAID induced ulcers?
Inhibits cAMP
Anticholinergic effect
Blocks 5-HT3
Enhances ATP
24
The doctor wants to start a LAMA. Which of the following structures would be the correct choice?
A
C
D
B
25
At which position is a keto group necessary for activity for glucocorticoids?
3
17
11
6
26
Which of the following increases selectivity of the following molecule?
Methylation on imidazole ring
Thioether
Imidazole
Cyano group
27
Which of the following does misoprostol mimic?
Pyrimidine
Cortisol
Prostaglandin
Receptors
28
Is this structure a direct, indirect or mixed acting B-2 agonist?
Indirect
I dunno
Direct
Mixed Acting
29
Which of the following is NOT true about Montelukast
MOA: anti-inflammatory and reduces bronchoconstriction
Classified as a Leukotriene receptor antagonist (LTRA)
Has a black box warning for ↑ risk of neuropsychiatric events
Helpful for treating acute asthma exacerbations
