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4S Clinical Trial Flashcards | StudBud
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4S Clinical Trial
4S Clinical Trial
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Questions
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Answers
1
The median follow-up time for this study was
5.4 years
6.2 years
3.5 years
8.1 years
2
How many patients were enrolled in the 4S study?
4444
4500
5555
4554
3
What is an example of exclusion criteria that was followed in 4S?
C. History of completed brain bleed
A. Premenopausal women of childbearing potential
Both A and B
B. MI during the preceding 12 months
4
What was the treatment the experimental group recieved in this trial?
Rosuvastatin
Fluvastatin
Atorvastatin
Simvastatin
5
What is the formal name of this study?
Scotland Simvastatin Survival Study of August 1988
Scandinavian Simvastatin Survival Study of April 1987
Scandinavian Simvastatin Susceptibility Study of August 1988
Scotland Simvastatin Susceptibility Study of April 1987
6
What Disease state did 4S focus on?
Hypercholesterolemia
Diabetes
CKD
Hypertension
7
The Simvastatin group in this trial...
Showed a greater instance of mortality compared to placebo
Would beat Texas Tech in a 3-game series
Showed no difference in mortality compared to placebo
Showed a lower instance of mortality compared to placebo
8
What type of trial was this?
All of the Above
Experimental vs. Placebo
Double-Blind
Multi-Center Randomized
9
Simvastatin prevented all-cause mortality at a rate of 1 patient per _____ over a median of 5.4 years. (The NNT)
60
15
30
45
10
The results of this trial were not statistically significant for the primary outcome.
True
False
11
Which of these was NOT in the inclusion criteria?
Men and Women ages 35-70
Concurrent use of a diuretic/vasodilator
Angina pectoris or previous MI
Serum cholesterol 5.5-8 mmol/L on a lipid-lowering diet
12
The main purpose of this trial was to show that the lowering of cholesterol prolongs life.
True
False
13
What was the primary outcome of this trial?
Atherosclerotic Events
Hospitalizations for CHD
All-cause Mortality
Myocardial Infarctions
14
The primary outcome (All-cause Mortality) had a higher NNT than the secondary outcome (Major coronary events).
False
True
