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Human Physiology 2 Body System Renal Compilation Quiz Flashcards | StudBud
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Human Physiology 2 Body System Renal Compilation Quiz
Human Physiology 2 Body System Renal Compilation Quiz
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Answers
1
What pumps NA+ out to keep the {Na+} inside the cell low?
Na+K+-ATPase on the basolateral membrane
K+NA+-ATPase on the mechanolateral membrane
K+NA+-ATPase on the basolateral membrane
Na+K+-ATPase on the mechanolateral membrane
2
Where are the majority of nephrons (80%) located in the kidney?
Capsule
Renal Pelvis
Medulla
Cortex
3
Presence of protein in the urine can indicate damage to the filtration barrier. This is called?
Haematuria
Glycosuria
None of the answers
Proteinuria
4
Which of the following is one of the limitations of carrier-mediated transport?
Carrier proteins are able to be excreted when at saturation
Carrier proteins are vulnerable to competition
Carrier proteins are invulnerable to competition
Carrier proteins can not be excreted when at saturation
5
The average number of nephrons in a human kidney is 5,000,000
True
False
6
In GFR, vasoconstriction of the afferent arteriole will reduce blood flow ____? the kidney
Inside
Outside
Out
Into
7
ECF volume is controlled by regulation 1.____ ECF osmolarity is controlled by regulation 2.____
1. Alkaline balance 2. Acid balance
1. Water balance 2. Salt balance
1. Salt balance 2. water balance
1. Acid Balance 2. Alkaline balance
8
Most body water is located in?
ICF of cells (Intracelluar fluid
ECF of cells (Extracellular fluid)
Interstial fluid
Blood
9
What is the path for filtered fluid through the tubular system? (LOH= Loop of Henle)
Bowman's capsule, proximal tubule, distal tubule, LOH
Bowman's capsule, distal tubule, LOH, proximal tubule
Bowman's capsule, proximal tubule, LOH, distal tubule
Proximal tubule, LOH distal tubule, Bowman's capsule
10
Filtration happens exclusively in the ____?
Renal Tubule
Peritubular capillaries
Bowman's capsule
Glomerulus
11
The ascending limb (LOH) is 1.____ to water but actively transports ions 2.____ of the tubule
1. Permeable 2. Into
1. Impermeable 2. Out
1. Impermeable 2. Into
1. Permeable 2. Out
12
Descending part of LOH is 1___ to water. Filtrate passes through it becomes 2____ concentrated.
1. Impermeable 2. Less
1. Permeable 2. Less
1. Permeable 2. More
1. Impermeable 2. More
13
In comparison to other capillary beds glomerular capillaries are important because?
2. Filtration occurs through entire length of capillary bed
1. Glomerular capillaries are highly permeable
Both 1 and 2
3. Acts as a sieve to prevent filtration of plasma proteins
14
Approximately ….....? of filtered fluid is reabsorbed in proximal tubule
99%
20%
10%
90%
15
What would happen to if you had a decrease in osmolarity and increase in ECF volume?
Drinking water after sweat loss
Incomplete compensation for dehydration
Drinking a large volume of water
Dehydration
16
Which of the following is
not
one of the import reasons for autoregulation of GFR?
Autoregulation of GFR prevent damage to filtration barriers
Autoregulation of GFR avoid imbalances in fluid/electrolytes
Mean blood osmotic pressure helps keep GFR fluids in balance
Mean arterial pressure is a critical determinant of GFR
17
Na+/K+-ATPase pumps 1.___ out of the epithelial cells also pumps 2.___ into epithelial cells.
1. K+ 2. K+
1. Na+ 2. Na+
1. Na+ 2. K+
1. K+ 2. Na+
18
Tubular secretion is the selective transfer of?
substances from tubular lumen to peritubular capillaries
substances from peritubular capillaries to tubular fluid.
substances from tubular fluid to peritubular capillaries
substances from peritubular capillaries to tubular lumen
19
If there was a decrease in blood pressure the RAS system would trigger a release of renin from?
The kidneys
The heart
The pituitary gland
The adrenal glands
20
In primary active transport, the energy comes directly from where?
ACP
AMP
ADP
ATP
21
The renin-angiotensin system (RAS) is a critical pathway for the regulation of?
Filtration
Water Excretion
Blood pressure
Water absorption
22
Are the synthesis of certain hormones one on the functions of the kidneys?
True
False
23
Micturition is a spinally-mediated reflex that is controlled both consciously and unconsciously
True
False
24
Regarding basal Lamina which of the following statements is false?
The negatively charge proteins help to repel plasma proteins
Extracellular matrix between glomerular and bowman’s capsule
Acts as a sieve to prevent the filtration of plasma proteins
Extracellular matrix contain positively charge glycoproteins
25
Which of following is correct regarding
passive
transport in tubular reabsorption?
Uses energy to transport substances against osmotic gradient
Uses electrochemical and osmotic gradient to move substances
Uses the potential energy from the concentration gradient
The energy comes directly from ATP
26
GFR is define as the 1____ of fluid that is filtered at the 2____ per unit time.
1. Type 2. Nephron
1. Volume 2. Nephron
1. Type 2. Glomerulus
1. Volume 2. Glomerulus
27
Vasopressin is produced in the 1.____ and stored in the 2._____
1. Cerebellum 2. Posterior Pituitary
1. Hypothalamus 2. Posterior Pituitary
1. Hypothalamus 2. Anterior Pituitary
1. Cerebellum 2. Anterior Pituitary
28
After the filtered fluid leaves the bowman's capsule it then flows into the?
Loop of Henle
Collecting duct
Distal tubule
Proximal tubule
29
Which are the 3 main systems the body uses to maintain pH homeostasis?
Chemical buffers, ventilation, renal regulation H+ and HCO3-
Chemical buffers, venous, renal regulation H+ and HCO3-
Chemical buffers, Expectiration, renal regulation H+ and Na+
Chemical buffers, ventilation, renal regulation H+ and Na+
30
The majority of renal blood flow regulation occurs at the ____? arteriole
Glomerulus
Distal
Efferent
Afferent
31
Which of the following is
not
one of the basic renal processes?
Deregulation
Secretion
Filtration
Reabsorption
32
Which is
not
one of the barriers that substances must pass through for kidney filtration?
Glomerular capillary endothelium
Basal Lamina
Proximal tubule
Bowman's capsule epithelium (podocytes)
33
During acidosis, intercalated cells 1.____ H+ and 2.____ HCO3
1. Absorb 2. Secrete
1. Secrete 2. Absorb
1. Secrete 2. Reabsorb
1. Reabsorb 2. Secrete
34
What is the path of blood flow in the kidneys? (AA=Afferent arteriole; EA= efferent arteriole)
AA, EA, glomerular capillaries, peritubular capillaries
AA, peritubular capillaries, EA, glomerular capillaries
EA, glomerular capillaries, AA, peritubular capillaries
AA, glomerular capillaries, EA, peritubular capillaries
35
The glomerulus is surrounded by?
Interstitial fluid
Bowman's capsule
Filtered fluid
Blood flow
36
Internal sphincters are made of smooth muscle and are?
Actively contracted
Concentrically contracted
Passively contracted
Eccentrically contracted
37
What drives water reabsorption in the proximal tubule across the epithelial layer?
Diffusion
Osmosis
Secondary Transport
Active transport
38
The peritubular capillaries surround the tubule and are where 1____? and 2____? occur
1. Absorption 2. Secretion
1. Reabsorption 2. Secretion
1. Reabsorption 2. Excretion
1. Absorption 2. Excretion
39
Approximately ….....? of the renal plasma flow is filtered into Bowman’s capsule
20%
90%
10%
99%
40
In the kidney, the concentration gradient of Na+ is often used to transport what substances?
Glucose, calcium, nitrogen ions
Glucose, amino acids, nitrogen ions
Glucose, amino acids, hydrogen ions
Glucose, calcium, hydrogen ions
41
In Tubular secretion; K+ can diffuse into the lumen via 1.___ channels on the 2.____ membrane
1. Filter 2. Luminal
1. Leak 2. Basolateral
1. Leak 2. Luminal
1. Filter 2. Basolateral
42
The stimuli for ANP (Atrial natriuretic peptide) release is caused by?
Decrease in ECF osmolarity
Increase in blood pressure
Decrease in blood pressure
Increase in ECF osmolarity
43
How would the body compensate for metabolic alkalosis?
↑ ventilation, conservation of H+ and excretion of HCO3-
↓ ventilation, conservation of HCO3- and excretion of H+
↑ ventilation, conservation of HCO3- and excretion of H+
↓ ventilation, conservation of H+ and excretion of HCO3-
44
Which of the following is
not
one of the main functions of kidneys
Excretion of xenobiotics
Deregulation of wastes
Regulation of pH
Regulation of fluid and electrolyte balance
45
Tubuloglomerular Feedback involves?
Regulation of the amount of Na+ and water in the tubule
Regulates amount of constriction to the afferent arteriole
Depolarization of smooth muscle cells
Hyperpolarization of smooth muscle
46
When there is an increase stretch in the bladder, what causes contraction of the smooth muscle?
Decrease sympathetic output
Increase parasympathetic output
Decrease parasympathetic output
Increase sympathetic out
47
Regarding glomerular capillary endothelium which of the following statements is
false
?
Mesangial cells are contractile, allowing blood flow
Cells are too large to pass through so they are retained
Glomerular capillaries are defenestrated
Contain large pores that allow most substances to pass
48
What creates a gradient for secondary active transport which moves dicarboxylates into the cell
Na+/K+-ATPase keeping intracellular Na+levels high.
Facilitated diffusion into the interstial fluid
Facilitated diffusion into the tubule lumen.
Na+/K+-ATPase keeping intracellular Na+levels low.
49
Which hormone increases the permeability of the collecting duct?
Insulin
Vasopressin (ADH)
Aldosterone
Testosterone
50
Ventilation regulates pH by controlling the rate of?
H+
CO2
O2
COOH
51
Which osmotic gradient allows urine more concentrated than the isoosmotic body fluids?
Vasopressin osmotic gradient
Vertical osmotic gradient
Interstitial osmotic gradient
Horizontal osmotic gradient
52
After leaving the efferent arterioles, bloods passes into a second capillary bed called the?
Sinusoids capillaries
Peritubular capillaries
Fenestrated capillaries
Continuous capillaries
53
Hypokalaemia is?
Low plasma K+
High plasma K+
Low plasma Na+
High plasma Na+
54
When dicarboxylates become concentrated inside the cell, this creates a gradient for?
Tertiary active transport
Facilitated diffusion
Secondary active transport
Primary active transport
55
Under chemical buffers the _____ buffer system is important for buffering changes in body pH
Potassium (K+)
Hydrogen (H+)
Bicarbonate (HCO3-)
Sodium (Na+)
56
Organic anions are mainly secreted into the?
Distal tubule
Proximal tubule
Tubule lumen
Collecting Duct
57
Where in the nephron does kidney filtration occur?
All the answers
Loop of Henle
Glomerulus
Collecting duct
58
Basic renal process- reabsorption is the 1__ movement and tubular secretion is the 2__ transfer
1. Exclusive 2. Exclusive
1. Selective 2. Exclusive
1. Selective 2. Selective
1. Exclusive 2. Selective
59
If a substance is filtered and reabsorbed but not secreted, Which is true?
Clearance < GFR
Clearance > GFR
Clearance = GFR
None of the answers
60
In hyperventilation, P
CO2
decreases also 1.____ H+ production creating an 2.____ state.
1. Increases 2. Alkalotic
1. Decreases 2. Acidotic
1. Decreases 2. Alkalotic
1. Increases 2. Acidotic
61
The Loop of Henle plays an important part in?
Production of co-enzymes for vassopressin
Regulation of glomerular filtration rate
Regulation of Na+, K+ and Cl-
Production of a concentrated urine
62
External sphincters are made of skeletal muscle and are controlled by ____ and stays contracted
Passive contraction
Nerve fibers
Active contraction
Motor neurons
63
Aldosterone is a steroid hormone that is produced by the?
Liver
Pituitary
Kidney
Adrenal gland
64
Which of the following is
not
a factor that would affect GFR?
Low plasma albumin
Low white blood cell count
Severe dehydrating diarrhea
Urinary tract obstruction
65
Which of the following is
not
one of the forces that drives filtration?
Bowman’s capsule hydrostatic pressure
Venous osmotic pressure (lymphatic pressure)
Glomerular capillary hydrostatic pressure
Plasma osmotic pressure (oncotic pressure)
66
Which of following is correct regarding
active
transport in tubular reabsorption?
Uses energy to transport substances against osmotic gradient
Uses the potential energy from the concentration gradient
Uses electrochemical and osmotic gradient to move substances
The energy comes directly from ATP
67
Secondary active transport uses the 1____ energy from the 2____ gradient of another molecule
Potential and concentration
Kinetic and concentration
Potential and membrane
Kinetic and membrane
68
Plasma clearance is defined as the 1.____ of plasma that is completely 2.____ of a substance
1. Rate 2. Absorbed
1. Rate 2. Cleared
1. Volume 2. Absorbed
1. Volume 2. Cleared
69
In micturition, apart from spinal reflexes what else modulates skeletal muscle?
Lymphatic System
Venous System
All of the answers
Central Nervous System
70
In secondary active transport Glucose enters the cell via _______?
Sodium-linked glucose transported (SGLT)
Glucose linked transporter (GLUT)
Diffusion
Action potential
71
Prolonged hypoventilation could cause which of the following?
Respiratory acidosis
Metabolic acidosis
Metabolic alkalosis
Respiratory alkalosis
72
Organic anion transporter secrete a range of 1.____ and 2.____ organic anions.
1. Inner 2. outer
1. Primary 2. Secondary
1. Endogenous 2. Exogenous
1. Intracellular 2. Extracellular
73
The kidneys receive ______? of cardiac output at rest
30-35%
20-25%
10-15%
40-45%
74
What would happen to if you had an increase in osmolarity and a increase in ECF volume?
Ingesting saline
Dehydration
Eating salt without liquids
Eating salty food with liquid
75
After transportation glucose then diffuses out of the cell across the 1___ membrane via a 2____
1. Epithelial 2. SGLT transporter
1. Basolateral 2. GLUT transporter
1. Epithelial 2. GLUT transporter
1. Basolateral 2. SGLT transporter
76
Where in the kidneys is HCO
3
- mainly reabsorbed in the kidneys?
Loop of Henle
Proximal tubule
Distal tubule
Collecting Duct
77
The ends of proximal tubule become more concentrated creating a 1_____ for the 2____ of
urea
1. Negative 2. Active transport
1. Negative gradient 2. Diffusion
1. Concentration gradient 2. Active transport
1. Concentration gradient 2. Diffusion
78
Vasopressin secretion is
stimulated
by?
Decrease ECF osmolarity, Loss in ECF volume
Decrease ECF osmolarity, Increase in ECF volume
Increase ECF osmolarity, Loss in ECF volume
Increase ECF osmolarity, Increase in ECF volume
79
In the basic renal process reabsorption occurs from the tubular lumen back into the _____?
Tubular fluid
Peritubular capillaries
Glomerulus
Bowman's capsule
80
Active regulation of acid-base balance occurs in the?
Distal tubule
Bowman's capsule
Proximal tubule
Collecting duct
81
What are the key steps of in the reabsorption movement of NA+ in the tubule?
Bowmans Cap>Proximal tube>Distal Tube>LOH>Collecting Duct
Bowmans Cap>Proximal tube>LOH>Distal tube>Collecting Duct
Bowmans Cap>LOH>Proximal tube>Distal tube>Collecting Duct
Bowmans Cap>Distal Tube>LOH>Proximal tube>Collecting Duct
82
How will drinking water after sweat loss affect ECF volume and osmolarity?
Increase in osmolority and no change in volume
Decrease in osmolority and no change in volume
Increase in osmolority and decrease in volume
Decrease in osmolority and increase in volume
83
Maintaining normal cell volume depends on the regulation of?
ECF volume
ECF pressure
ECF potential
ECF osmolarity
84
Secretion of K+ is regulated by the adrenal hormone
Cortisol
DHEA
Testosterone
Aldosterone
85
GFR regulation, the afferent and efferent arterioles are both vessels that can be __? regulated
Selective
Independently
Dependently
Exclusive
86
Tubular secretion is the transfer of substances from the peritubular capillaries to the ____?
Glomerulus
Tubular fluid
Tubular lumen
Peritubular capillaries
87
Outside of local mechanisms for regulating GFR, renal arterioles are innervated by ___? neurons
Kidney
Parasympathetic
Sympathetic
Endocrine
88
What would happen to if you had a no change in osmolarity and a decrease in ECF volume?
Haemorrhage
Incomplete compensation for dehydration
Eating salty food with no liquid
Ingesting isotonic saline
89
Which of the following is true in regards to aldosterone?
Increases Na+ reabsorption, increase K+ secretion
Decreases Na+ reabsorption, Decrease K+ secretion
Decreases Na+ reabsorption, increase K+ secretion
Increases Na+ reabsorption, Decrease K+ secretion
90
Which of the following is NOT a feature of autoregulatory myogenic response?
Depolarisation of the vascular smooth muscle cells
Myogenic response increase MAP, increase afferent arteriole
Activates smooth muscle > stretch-sensitive ion channels
Activates paracrine mediators, change amount of Na+ & water
91
Aldosterone release can be triggered by?
Reduction in blood pressure or increase Na+ levels
Reduction in blood pressure or increase K+ levels
Increase in blood pressure or increase Na+ levels
Increase in blood pressure or increase K+ levels
92
In the kidney, which one of these fluids has the highest osmolarity
Fluid at the lowest parts of the Loop of Henle
Fluid leaving via the distal tubule
Fluid in the ascending limb of the Loop of Henle
Fluid entering the descending limb of the Loop of Henle
93
Regarding Podocytes which of the following statements is false?
They have short extensions that wrap around the lamina
The slits that form are the final barrier to filtration
Cells and plasma proteins are retained within the blood
Podocytes surround the glomerular capillary
94
Which of the following are the 2 acid-base disturbances?
Metabolic and Anaerobic
Respiratory and metabolic
Respiratory and Anaerobic
Metabolic and catabolic
95
Reabsorption can be either 1___ (between cells) or 2___ (across cells)
1. Intercellular 2. extracellular
1. Intracellular 2. extracellular
1. Paracellular 2. transcellular
1. Transcellular 2. paracellular
96
Before you start seeing adverse effects _____? of renal capacity would need to occur
80-85%
90-95%
100%
70-75%
97
Atrial natriuretic peptide (ANP) is produced where?
Adrenal glands
Nephron
Kidney
Heart
98
The juxtamedullary nephrons, which have 1____ loops that extend into the 2____
1. Short 2. Medulla
1. Long 2. Cortex
1. Long 2. Medulla
1. Short 2. Cortex
99
In the proximal tubule, Na+ is important for 1____ for of substance such as 2____
1. Absorption 2. Urea
1. Reabsorption 2. Urea
1. Absorption 2. Glucose
1. Reabsorption 2. Glucose
100
In carrier-mediated transport the plasma concentration at which saturation occurs is the?
Transport maximum
Renal Threshold
Carrier maximum
Saturation Maximum
101
Sodium is a 1____ charged ion. This sets up a gradient for 2____ charged ions such as 3____
1. Positive 2. Negative 3. Cations
1. Negative 2. Positive 3. Anions
1. Positive 2. Negative 3. Anions
1. Positive 2. Negative 3. Cations
102
When saturation occurs the rate of transport cannot increase any further. This is known as the?
Renal Threshold
Transport maximum
Carrier maximum
Saturation Maximum
103
Saturation
occurs when all available 1._____ are fully occupied by 2._____
1. Carriers 2. Carrier cells
1. Carriers 2. Substrate molecules
1. Cells 2. Carrier cells
1. Cells 2. Substrate molecules
104
Which of the following is a cause of respiratory disturbance that effect pH?
Hyperventilation
Hypoventilation
All of the answers
Severe diarrhea
105
Which of the following are the main factors in regulation GFR?
2. Renal blood flow
None of the answers
Both 1 and 2
1. Net filtration pressure
106
In regulation, the kidneys can control pH by adjusting either the excretion of
Bicarbonate or potassium
Hydrogen or Bicarbonate
Hydrogen or sodium
Bicarbonate or Sodium
107
Net filtration is glomerular capillary pressure, plasma osmotic pressure and Blood pressure?
False
True
108
How does the body respond to salt ingestion?
Decrease ECF osmolarity, Suppression of vasopressin
Decrease ECF osmolarity, Secretion of vasopressin
Increase ECF osmolarity, Suppression of vasopressin
Increase ECF osmolarity, Secretion of vasopressin
109
ECF volume is important for 1_____. ECF osmolarity is important for preventing 2_____
1. Maintaining blood volume 2. Shrinkage/swelling of cells
1. Maintaining blood volume 2. Acidosis of cells
1. Maintaining blood pressure 2. Acidosis of cells
1. Maintaining blood pressure 2. Shrinkage/swelling of cells
110
Where are the receptors that vasopressin reacts to?
Collecting duct
Pertiubular capillaries
Proximal tubule
Loop of Henle
111
Blood enters the kidneys via the renal ____?
Venules and capillaries
Venules and veins
Arteries and arterioles
Arteries and capillaries
112
Vasopressin secretion is
suppressed
by?
High ECF osmolarity, Increase ECF volume
Low ECF osmolarity, Increased ECF volume
Low ECF osmolarity, Decreased ECF volume
High ECF osmolarity, Decreased ECF volume
113
Carrier-mediated transport are unsaturable because any filtered fluid gets reabsorbed.
True
False