Lab Evaluation of Hemostatsis

What tube is used to run vWf assays? How is it reported?

FDPs refers to any protein fragments that can be produced when either fibrinogen or fibrin is cleaved by plasmin

If there is a prolonged PT and PTT, where is the deficiency?

What is the indication for BMBT?

What is the most common inherited hemostatic disorder?

Jellybean, an 8-year-old F(s) Pothound has a [Plt] of 55,000 ul[RI: 150k/ul-500k/ul]. What’s your next step?

What are the test for fibrinolysis, that measure the clot breakdowns?

APTT/PT can be falsely prolonged in cases of?

What pathway is PTT in?

What is a FDP a marker for?

FDPs and D- dimers usually run alongside PT/PTT to test for DIC

If there is a prolonged PT and normal PTT, where is the deficiency?

What pathway is ACT in?

If the citrate tube is underfilled→ Anticoagulant and artificial prolongation of PT/PTT

What tube is used to run ACT- Activated Clotting Time? How is it reported?

What is the range of platelets during a bleeding 2' to trauma?

increased [FDPs/D-dimers] means fibrinolysis is occurring at an accelerated rate

Coagulation is limited to the site of vascular injury because:

What enzyme is responsible for cleaving fibrin during the 3’ coagulation process?

What are examples of tests that check for primary hemostasis?

What does aggregometry testing evaluate?

If there is a prolonged PTT (intrinsic and common) but a normal PT (extrinsic and common) where is the deficiency?

Whats important when doing the BMBT?

D-dimers are a specific sub-set of FDPs and have mostly replaced FDPs

When can an increase in FDP/ D-dimers be seen?

When is a BMBT test indicated?

What are the results of D-dimers normally seen with trauma, post surgery, and liver disease?

Abnormal bleeding time = any problem with 1’ hemostatic system (Plt #s,Plt fn, vWD

ACT can be falsely prolonged (mild) in cases of:

What is the normal bleeding time for dogs?

What is a potential manifestation of Disseminated Intravascular Coagulation (DIC)?

If abnormal BMBT, normal [PLT] and [vWf]→ patient probably has a plt function defect

What is the range of platelets during a spontaneous bleed?

What does the APTT measure? What also needs to be done along side it?

When does vWF disease become apparent?

Abnormalities with platelet function is usually inherited

What concentrations are particular for thromboembolism, because other conditions do not USUALLY get to this magnitude?

What does BMBT - buccal mucosal bleeding time evalute?

What is the normal range of platelets?

What are the differentials for primary hemostasis?

What does the PT/OPST measure?

What is the relevance of Calcium in the coagulation cascade?

What pathway is PT in?

Citrated plasma- can use the same sample submitted for PTT/PT

Tests are abnormal if results are prolonged

What is the only factor not evaluated in the ACT?

Severe thrombocytopenia <10,000/ul can cause MILD prolongation of ACT