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Rad Bio Part 2 (SLewis) Flashcards | StudBud
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Rad Bio Part 2 (SLewis)
Rad Bio Part 2 (SLewis)
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1
Which of the following cell types are likely to express radiation injury after a D0 dose of radiation is received?
FPM
DIM
VIM
RPM
2
When oxygen is present, the cell is:
Radioresistant
The same
Dead
Radiosensitive
3
The TD 5/5 indicates the dose required to cause a 5% chance of injury to people irradiated within __ following exposure:
5 days
5 minutes
5 hours
5 years
4
What organ has a TD 5/5 of 23 Gy?
Kidney
Ovary
Lung
Heart
5
At what dose (Gy) are cataracts initially observed?
2
15
10
20
6
Epilation may initially be observed in patients at an approximate dose of:
15 Gy
5 Gy
30 Gy
50 Gy
7
Which of the following is a more accurate representation of cell radiosensitivity?
LD 50/30
n
Dq
Do
8
What is the name of the largest saliva gland?
Submantle
Sublingual
Submandibular
Parotid
9
The TD 5/5 for the whole brain using standard fractionation is approximately:
15 Gy
45 Gy
50 Gy
60 Gy
10
When ionizing radiation interacts with a key molecule, the sensitive area is termed target. Name this theory:
Cell Theory
Molecular Theory
Law of Bergonie + Tribondeau
Target Theory
11
When ionization events occur in the target it is termed:
Proliferation
Extrapoliation
Hit
Mitosis
12
The onset of dose for wet desquamation during standard fractionation is ___ Gy:
15
40
20
30
13
What are the 4 major classes of organic compounds?
Lipids, Carbohydrates, Carbon, Phosphorus
Proteins, Lipids, Carbohydrates, Nucleic Acid
Proteins, Phosphorus, Nucleic Acid, Lipids
Lipids, Phosphorus, Nucleic Acid, Carbohydrates
14
Without medical intervention, a person exposed to a single whole body dose of _____ may die within 10 days.
0.25 Gy
10 Gy
1.0 cGy
1.0 Gy
15
The TD 5/5 for the ovary is ____________ than the TD 5/5 for the lung.
Higher
Lower
16
Which of the following would be a stochastic or late radiation response?
Sterility
Skin Erythema
Lung Cancer
Bone marrow suppression
17
Irradiation of the salivary glands may lead to permanent xerostomia above doses of
10 Gy
30 Gy
20 Gy
40 Gy
18
If 1/3 of the esophagus receives a dose of 6500 cGy, what would most likely be the effect?
Obstruction
Obstruction
Perforation
Fistula
19
What type of cell fate is traced by chromosome damage?
Interphase death
Division Delay
Lethal Delay
Reproductive Failure
20
What does the term interphase death mean?
The cell dies prior to entering interphase
The cell dies between mitotic phases
The cell dies prior to leaving interphase
The entire organism dies
21
Reddening of the skin is:
Erythema
Myelitis
Xerostomia
Epilation
22
What is the TD 5/5 for stomach?
50 Gy
20 Gy
65 Gy
40 Gy
23
If a cell is hypoxic it is:
Radiosensitive
Without oxygen
Stagnant
With oxygen
24
Which of the following is a characteristic of a heavy charged particle?
Large mass
Travels further than electrons
Zig-zag path
Changes direction quickly
25
In RNA, what nitrogenous base replaces Thymine?
Guanine
Cytosine
Uracil
Adenine
26
Which acute radiation syndrome would occur after a radiation dose of 1,000 cGy to the entire body?
Gastrointestinal Syndrome
Cerebrovascular syndrome
Hematopoietic Syndrome
Plummer-Vinson Syndrome
27
The loss of hair is:
Epilation
Xerostomia
Myelitis
Erythema
28
At doses above _____ Gy, you may see latent stricture in the espohagus during standard fractionation.
60
10
40
5
29
What is the TD 5/5 for the bladder in Gy?
65
20
50
40
30
Which of the following terms is used to describe radiation damage to a cell that is not sufficient to kill the cell?
Division Delay
Relative Biological Effect
Lethal damage
Sublethal damage
31
Which phase of the cell cycle occurs between the two gap phases, G1 and G2?
Telophase
Metaphase
Interphase
Synthesis
32
The TD 5/5 for the colon is ________ than the TD 50/5 of the colon.
Lower
Higher
33
What is the typical oxygen enhancement ratio (OER) value for sparsely ionizing radiation?
0.5 to 1.0
2.5 to 3.0
Greater than 3.0
1.0 to 2.0
34
Which of the following is an effect of radiation on DNA?
Hydroxyl Formation
Free Radical formation
Cross-linking
Increased Viscosity
35
If the same cell type replaces cells within this organ, what has occurred?
Regeneration
Repair
36
Dry mouth is:
Myelitis
Gingivitis
Thrush
Xerostomia
37
Tolerance dose to 3/3 of the kidney according to Emami et al?
4500 cGy
5000 cGy
3000 cGy
2300 cGY
38
Which of the 4 Rs of biologic effectiveness is least desirable for malignant cells?
Redistribution
Repopulation
Reoxygenation
Regeneration
39
The TD 5/5 is ______________ for immature bone than for mature bone.
Lower
Higher
40
Protracted or fractionated doses are better tolerated by tissue than single doses because:
Tolerence increases as dose increases
repair occurs between exposures
Fewer cells will be struck by radiation
damage cannot occur in previously killed cells
41
What type of radiation consists of photons that were naturally produced from the nucleus?
Beta Particles
Gamma Rays
Alpha Particles
X-rays
42
At 20 Gy, what may initially be observed in patients receiving radiation under standard fractionation scheme?
Fistula of colon
Moist Desquamation
Temporary sterility
Erythema
43
After a dose of 300 cGY to the tetes, sterility is most likely
Temporary
NO effect
Permanent
Acute
44
A well-differentiated cell is:
Radiosensitive
Radioresistent
45
What is the most potent radiosensitizer?
Chemotherapy
Bolus
Oxygen
Radiation
46
At what dose would we expect reddening of the skin?
20 Gy
30 Gy
40 Gy
15 Gy
47
Which of the following is not a nitrogenous base found in DNA?
Adenine
Thymine
Guanine
Uracil
48
A fistula is likely at what dose to the colon?
20 Gy
55 Gy
49
If a different type of cell type replaces cells within this organ, what has occurred?
Repair
Regeneration
50
As LET __________, Dq on the cell survival curve becomes ___________:
increases, larger
increases, smaller
51
What is the most abundant molecule in the body?
Protein
Lipids
DNA
Water
52
Permanent sterility occurs at ____ cGy:
500
400
200
300
53
The four Rs of radiation biology are:
Reoxygenation, reimplantation, redistribution, repair
Reoxygenation, repair, repopulation, reduction
Reoxygenation, repopulation, redistribution, repair
Reoxygenation, repopulation, reimplantation, redistribution
54
Which somatic effect does NOT have a threshold?
Direct Effects
Indirect Effects
Stochastic
Non-stochastic
55
Protracted or fractionated doses are better tolerated by tissue than single doses because:
Tissue tolerace increases as dose increases
Fewer cells will be struck by radiation
Tissue repair occurs between exposures
Radiation damage cannot occur in previously killed cells
56
The TD 5/5 is ______________ for bone marrow irradiated in a single dose than a fractionated dose.
Lower
Higher
57
What cell structure is known as the “Power Plant” and is responsible for energy production?
Lysosome
Mitochondria
Ribosome
Nucleus
58
As LET __________, Dq on the cell survival curve becomes ___________:
decreases, larger
decreases, smaller
59
Normal tissue healing following radiation occurs by:
Regeneration
Repair
Revitalization
Regeneration AND Repair
60
What percentage of radiation induce damage occurs as a result of indirect ionization?
70%
15%
30%
1%
61
Which term describes certain chemicals or drugs that enhance the response of cells to radiation?
Free Radicals
NSAIDs
Radiosensitizers
Radioprotectors
62
Conventional fractionation was based on the experiments performed to:
Sterilize rams
Eradicate tumors in mice
Produce skin reactions in rams
Induce tumors in mice
63
What is the threshold dose to the lens needed to cause blindness?
500 cGy
5000 cGy
100 cGY
1000 cGY
64
When does permanent epilation occur?
40 Gy
15 Gy
45 Gy
20 Gy
65
Exceeding the TD 5/5 for the spinal cord may lead to:
Obstruction
Ulceration
Perforation
Myelitis Necrosis
66
Erythematous skin reactions during fractionated radiation therapy are seen as a result of:
Extreme heat to the skin area
Vascular dilation in the area
Regeneration of skin cells in the area
Loss of skin cells in the area
67
The most radiation-sensitive target molecule.
Cytoplasm
DNA
RNA
Protein
68
On a cell survival curve, if the Do measures small, it will:
respond to radiation quickly
not respond to radiation quickly
69
Which somatic effect depends on the severity of the radiation dose?
Stochastic
Non-stochastic
Indirect Effects
Direct Effects
70
If a cell is aerobic it is:
Without oxygen
With oxygen
Radiosensitive
Stagnant