L42 Drug Drug Interactions

Question 1

In complex formations, what does Calcium react with?

Accepted Answer

NaHCO3, Cephalosporins, Barbiturates & some NSAIDS

Question 2

What defines a “safe” drug

Accepted Answer

At high concentration and for long periods of time, Non habit forming, No side effects, Reduced by improper admin

Question 3

What are the pharmacodynamic effects of drug interactions

Accepted Answer

Antagonism, Additive effects, Synergistic effects

Question 4

What is true of metabolism drug reactions

Accepted Answer

Inhibit P450, Metabolic rate increase, Metabolic rate inhibition inhibits hepatic enzymes

Question 5

Reversible drugs will subside within a specific period of time

Accepted Answer

True

Question 6

Tetracyclines are oxidized by phenothiazine tranquilizer

Accepted Answer

Oxidation / reduction

Question 7

What do additive effects do?

Accepted Answer

Propanolol beta blocker verapamil Ca blocker they enhance vasodilation, Produce a response equal to the sum of the individual

Question 8

Beta lactams work best in rapid growing bacteria but tetracyclines are bacteriostatic

Accepted Answer

True

Question 9

Which of the following are pharmacokinetic things

Accepted Answer

Distribution, Excretion, Absorption

Question 10

Plasma protein binding: displacement of one drug leads to increased plasma free fraction

Accepted Answer

True

Question 11

Renal excretion has what major factors

Accepted Answer

Glomerular filtration - nephrotoxicity by NSAIDS impact GFR, Passive tubular secretion, Active tubular secretion probenecid & penicillin

Question 12

Plasma / tissue levels altered

Accepted Answer

Pharmacokinetics

Question 13

Antagonism

Accepted Answer

1+1=0

Question 14

What is true of an adverse drug event?

Accepted Answer

Lack of desired effect, Lack of desired effect, Center for vet med says any side effect injury toxicity or rxn

Question 15

What impacts glomerular filtration?

Accepted Answer

Nephrotoxicity by NSAIDS

Question 16

Gastric pH - ride in gastric pH decrease acid and decrease absorption

Accepted Answer

Antacids

Question 17

What are some examples of synergistic effects?

Accepted Answer

Furosemide leads to hypokalemia potentiating ionotropic digoxin, Furosemide potentiates nephrotoxicity of aminoglycosides, Aminoglycoside potentiates mm relaxation effects of anesthesia, Inhbitor of dihydrofolate synthetase and suldonamide

Question 18

H1 Antihistamine also blocks muscarinic receptors leading to mydriasis antagonizing the mitotic drug

Accepted Answer

True

Question 19

Elicits the response for which it is given for specific reaction with no side effects

Accepted Answer

Selective

Question 20

Know how patient will respond

Accepted Answer

Predictable

Question 21

What does the antimotility drug atropine do?

Accepted Answer

Decrease motility and movement to small intestine decrease absorption

Question 22

Which of the following are drugs that increase motility and absorption (promotility)

Accepted Answer

Cisapride, Metaclopramide

Question 23

Pharmaceutic - chemical or physical interactions of drugs mixed in vitro

Accepted Answer

True

Question 24

What are interactions affecting renal excretion

Accepted Answer

Decrease active secretion - competition for active transport, Increased passive secretion urinary pH ion trapping diuretics

Question 25

Macrocyclic lactones in water and aqueous solution will precipitate - amphotericin B is insoluble in water

Accepted Answer

Physical drug reaction examples

Question 26

Pharmacodynamic - action / effect is altered

Accepted Answer

True

Question 27

What drugs can form insoluble complexes with divalent cations?

Accepted Answer

Tetracycline and calcium, Antacids and ciprofloxacin

Question 28

Which of the following are examples of antagonism?

Accepted Answer

Tetracycline and beta lactam antibiotic, Mitotic drug and H1 antihistamine, Alpha adrenergic agonist and phenothiazine tranquilizer

Question 29

Drug elicits response intended

Accepted Answer

Efficacious

Question 30

How do alpha adrenergic agonists and phenothiazine tranquilizers work

Accepted Answer

Blockade of alpha receptors unmask beta agonism, Phenothiazines can block alpha adrenergic receptors

Question 31

What are chemical drug reactions?

Accepted Answer

Complex formation, Oxidation / reduction reactions, pH reactions

Question 32

You can mix drugs in a syringe and add them to parenteral solutions regardless of your knowledge of the compounds

Accepted Answer

False

Question 33

Physical drug reactions are usually due to solubility

Accepted Answer

False

Question 34

Active tubular secretion can be disrupted by probenecid and penicillin

Accepted Answer

True

Question 35

Alkaline solutions are incompatible with acidic solutions

Accepted Answer

True

Question 36

Chemical stability = able to use compound for a long time and increase shelf life

Accepted Answer

True

L42 Drug Drug Interactions

Questions 36

L42 Drug Drug Interactions

Questions 36