Duplicate of Bugs & Drugs Pulmonology

What is the mechanism of action of fluoroquinolones (moxifloxacin, levoflaxacin, ciprofloxacin, ofloxacin)?

Tdap is indicted every _______ years with caveats.

AE: neutropenia, neurotoxicity including status epilepticus, superinfection

Babies get Dtap, but at what age does a child get a Tdap booster?

In general, as you increase in generation of cephalosporins, you gain ________ coverage but lose ________ coverage.

Inhibits metabolite synthesis

Patient education should include the inhibition of birth control and the need for condom use

There is a vaccine for strep pneumoniae.

Which antibiotic used for TB can cause orange tears, sweat, and urine?

Which of the following RSV vaccines is preferred in pregnancy (32-36 weeks)

Tendonopathy, CNS toxicity, aortic aneurysm, prolonged QTc, and superinfection are adverse events caused by ________

When is Tdap given during pregnancy?

Which of the following is FALSE about fluoroquinolones?

What is the mechanism of action of tetracyclines (doxycycline, minocycline, tetracycline, tigecycline)?

All covid vaccine have a high risk of myocarditis and thrombocytopenia syndrome

blocks replication of influenza by preventing transcription of viral mRNA; not recommended in pregnancy or children <12y

Which of the following is category C for pregnancy and lactation?

Common among community pathogens, acquired resistance to PCN, amox, ampicillin

AE: fever and rash

Tdap is given to someone with a "dirty" wound if it has been > _____ years since their most recent Tdap.

SOA: narrow spec for gram positive cocci, hospital acquired MRSA, VRSA, VRE

1st line for ESBL gram negs, pseudomonas and reserved for critically ill pts

Esophagitis, photosensitivity rash, and staining of teeth in children are adverse events caused by ________

AE: delirium and serious drug rashes

The RSV vaccine is a recombinant vaccine (glycoprotein F)

Which of the following is category D for pregnancy and lactation?

Uncommon; destroy nearly all Beta lactam abx

AE: anemia, neutropenia, thrombocytopenia, serotonin syndrome if with antidepressants

Disrupts mycolic acid synthesis

What is the mechanism of action of macrolides (azithromycin, clarithromycin, erythromycin, fidaxomicin)?

Increased GI peristalsis, prolonged QTc, and ototoxic (high/prolonged doses) are adverse events caused by ________

Fluoroquinolones are contraindicated in children < 16 y/o

Common among hospital pathogens

Contraindicated in pts with CHF

SOA: gram negs , carbenemase producing gram negs, pseudomonas , CRITICALLY ILL PTS

Which of the following is the only 4th generation cephalosporin?

forms leaks in fungal cell membrane

SOA: MSSA, gram negs, pseudomonas, ESBL producing strains at high doses

Which of the following is FALSE about tetracyclines?

AE: lowers seizure threshold

Who is eligable for the new RSV vaccine?

Inhibits ergosterol synthesis

Neuropathy, blood dyscrasias and avoid alcohol

AE: severe rigors/ fever, N/V, decreased serum calcium, Avoid administration with other nephrotoxic drugs