stud
bud
Sign up
Log in
Home
Library
Explore
SAT
More
Journal Club: Etanercept in Kawasaki's Disease Flashcards | StudBud
Explore
/
Journal Club: Etanercept in Kawasaki's Disease
Journal Club: Etanercept in Kawasaki's Disease
10 terms
·
StudBud Administration
·
12 plays
Ali Aldieri Page Holsteen PGY1 Pharmacy Residents
Flashcards
10 cards
F
Practice quiz
P
Host live
L
Questions
10
Answers
1
What is a typical subcutaneous dosing regimen of etanercept for IVIG-resistant KD?
2 g/kg once shortly after IVIG infusion
5 mg/kg once shortly after IVIG infusion
0.8 mg/kg shortly after IVIG infusion + 2 weekly doses
0.2 mg/kg shortly after IVIG infusion + 2 weekly doses
2
What is the primary therapeutic goal in treating Kawasaki disease?
Increasing core body temperature
Reducing pain
Preventing coronary artery dilation
Preventing TNF-alpha production
3
True/False: TNF-alpha inhibitor + IVIG significantly increases the risk for adverse events compared to IVIG alone.
True
False
4
What is NOT a symptom included in the major diagnostic criteria of KD?
Coronary artery dilation
Swollen, red feet
Strawberry tongue
Fever >5 days
5
What is the current recommended initial regimen to treat Kawasaki disease?
IVIG + high-dose ASA
IVIG + low-dose ASA
IVIG + high-dose ASA + infliximab
IVIG + NSAID
6
What is the definition of IVIG-resistant Kawasaki's disease?
Persistent fever at >36 hours, <7 days after IVIG
Persistent conjunctivitis at >36 hours, <7 days after IVIG
Persistent fever at >72 hours, <7 days after IVIG
Recurrent rash at >72 hours, <7 days after IVIG
7
True/False: In the primary article, etanercept significantly reduced IVIG resistance in all age groups.
False
True
8
What was the most common reported adverse effect in the etanercept group?
Infections
Elevated transaminases
GI symptoms
Headache
9
What patient population has the most data for treatment of Kawasaki's disease?
North American children
African American children
Chinese children
Japanese children
10
In what patient subgroup did etanercept significantly reduce the IVIG resistance rate?
>5 years of age
>1 year of age
<1 year of age
<5 years of age
