stud
bud
Sign up
Log in
Home
Library
Explore
SAT
More
2024-2025 Quiz #5 Feb 14, 2025 Flashcards | StudBud
Explore
/
2024-2025 Quiz #5 Feb 14, 2025
2024-2025 Quiz #5 Feb 14, 2025
42 terms
·
StudBud Administration
·
10 plays
Chapter II-3, Lung (pages 227-280) and Chapter VII-1, Emerging Health Priorities (pages 543-550)
Flashcards
42 cards
F
Practice quiz
P
Host live
L
Questions
42
Answers
1
Which of the following is true about Allergic Bronchopulmonary Aspergillosis (ABPA)?
Peripheral bronciectasis is a hallmark finding on chest CT
ABPA pathology is secondary to colonization, not local invasion
A lack of Aspergillus sensitization is seen in as many as 30% of ABPA pts
CF & asthma patients develop ABPA < the general pop ulation
2
Which of the following is NOT a risk factor for E-cigarette or vaping use-associated lung injury (EVALI)?
Male Sex
Older age (>40 y/o) when starting use of e-cigarette products
E-cigarette products containing Vitamin-E
E-cigarette products containing THC
3
Which form of bronchoprovocation testing does not require cell mediator release/ acts on airway smooth muscle receptors?
Methacholine
Bradykinin
Cold air
Mannitol
4
Cardiac involvement is the leading cause of mortality in this disease
Granulomatosis with Polyangiitis (GPA)
Sarcoidosis
Microscopic polyangiitis (MPA)
Eosinophilic Granulomatosis with Polyangitis (EGPA)
5
Which of the following has NOT been shown to be a health care disparity related to ICU admission for asthma in kids?
Sensitized to mouse
Sensitization to Dust Mite
Living in poverty
Use albuterol more than prescribed
6
Which factor can
decrease
a patient's DLCO measurement on PFTs?
↓ Hemoglobin
L→R cardiac shunt
Exercise
Supine positioning
7
Which of the following treatments has not been shown to prolong the life of COPD patients?
ICS, LABA, LAMA triple therapy
Lung volume reduction surgery
Supplemental oxygen used 24 hours/ day
Smoking cessation
8
Which of the following is most likely to
decrease
a FENO reading?
Acute bronchitis
Competing in the Nathan's hot dog eating contest just before the test
Smoking
Patient holding his/ her ICS controller medication for 1 week prior to test
9
Early sensitization to which mold listed below has been strongly associated with asthma pathogenesis?
Penicillium
Aspergillus
Alternaria
Cladosporium
10
Which of the following is a 'hallmark of fatal asthma'?
Angiogenesis
Neutrophil accumulation in the airway
AIrway smooth muscle hypertrophy
Mucous gland hypertophy
11
Which of the following lower airway changes is
more associated with COPD
than asthma?
Predominately CD3+CD4+CD25+ celliular infiltrate
Fragile or denuded epithelium
↑ acidic glycoprotein in mucus
Thickened reticular basement membrane
12
Which cell type is the major producer of lung surfactant?
Pulmonary neuroendocrine cells (PNECs)
Type II pneumocytes
Type I pneumocytes
Goblet cells
13
Which pulmonary function is the most reproducible & primary outcome measure in most FDA phase III asthma drug trials?
FEV1 : FVC
FVC
TLC
FEV1
14
Following pulmonary/ sinus involvement, patients with EGPA most commonly experience which organ involvement?
Renal / Pauci-immune crescentic glomerulonephritis
Nervous System/ Mononeuritis multiplex
Gastrointestinal/ Eosinophilic gastroenteritis
Cardiovascular/ MI
15
In children, which PFT measurement declines most reliably as asthma severity increases?
FEV1
FEV1/ FVC
FVC
FEV1 25-75
16
Which of the following is FALSE regarding treatment of COPD?
ICS medications are not recommended for treatment of COPD
LAMAs are more effective than LABAs in preventing exacerbations
LABAs improve FEV1 & dec hospitalizations in COPD pts
PDE4 inhibitors are associated with increased exacerbations in severe COPD
17
Adult onset (steroid dependent) asthma, CRS, migratory pulmonary opacities, vasculitis of the vasa nervorum.
Sarcoidosis
Granulomatosis with Polyangiitis (GPA)
Eosinophilic Granulomatosis with Polyangitis (EGPA)
Microscopic polyangiitis (MPA)
18
The following PFT loop is most consistent with:
Obstructive abnormality
Variable extrathoracic obstruction
Fixed upper airway obstruction
Restrictive abnormality
19
A 26 y/o lab tech w/ AR but no history of asthma presents w/ new onset cough/ wheezing. PFT- reversible obstruction.
Occupational non-asthmatic eosinophilic bronchitis
Occupational rhinitis
Work exacerbated asthma
Sensitizer induced occupational asthma
20
Which occuapational asthma trigger is believed to have a pathophysiology related to complement activation?
Plicatic Acid
Isocyanates
Potassium Dichromate
Anhydrides
21
A class IV CF mutation. Patient have a partially functioning CFTR gene and milder symptoms vs class I-III.
ΔF508
R117H
G542X
G551D
22
ATS/ ERS defines a defines a significant bronchodilator response in
adults
as:
An increase of ≥12 % and ≥0.2 L from baseline
An increase of ≥12 % or ≥0.2 L from baseline
A change of >12% relative to the predicted value for FEV1 or FVC
A change of >10% relative to the predicted value for FEV1 or FVC
23
12 m/o has 2 days of fever, rhinorrhea & develops acute onset of cough & stridor and CXR below. True statement?
IM Epi is 1st line Tx for acute respiratory distress from stridor
The most common cause is parainfluenza types 1 & 2
This condition is most common in Spring and early Summer
The most common cause is S. pneumoniae
24
Males> Females, constitutional systems, alveolar hemorrhage w/ ground-glass infiltrates, p-ANCA/MPO-ANCA up to 75%
Sarcoidosis
Granulomatosis with Polyangiitis (GPA)
Eosinophilic Granulomatosis with Polyangitis (EGPA)
Microscopic polyangiitis (MPA)
25
This CF treatment has been shown to reduce sputum viscosity and the need for antibiotics.
Inhaled recombinant human deoxyribonuclease
Azithromycin 3 times a week in school aged children
Inhaled glucocorticoids
Fat-soluble vitamin supplementation (ADEK)
26
ATS/ ERS defines a defines a significant bronchodilator response in
children
as:
A change of >10% relative to the predicted value for FEV1 or FVC
A change of >12% relative to the predicted value for FEV1 or FVC
An increase of ≥12 % and ≥0.2 L from baseline
An increase in FEV1 of ≥12 % from baseline
27
The sputum finding in asthmatics pictured below is primarily made of which protein?
Galectin-10
Eosinophil peroxidase (EPX)
Eosinophil-derived neurotoxin (EDN)
Major Basic Protein (MBP)
28
41 y/o female who is a welder presents for new onset cough, wheezing & chest tightness. Most likely tigger?
Isocyanates
Plicatic Acid
Potassium Dichromate
Anhydrides
29
Which bronchoprovocation test is recommended for evaluating elite athletes for Exercise induced bronchospasm (EIB)?
Methacholine challenge:
Eucapnic voluntary hyperpnea (EVH)
Exercise challenge
Mannitol challenge
30
Which of the following best describes high levels of FENO in adults & children?
FENO > 50 ppb in both children and adults
FENO > 50 ppb in adults and >35 ppb in children
FENO > 35 ppb in both children and adults
FENO > 50 ppb in children and >35 ppb in adults
31
8 y/o male w/ nasal polyps & digital clubbing (& h/o SBO & rectal prolapse). Most common Acid/ base d/o?
Hypernatremic, hyperchloremic, metabolic acidosis
Hypernatremic, hyperchloremic, metabolic alkalosis
Hyponatremic, hypochloremic, metabolic acidosis
Hyponatremic, hypochloremic, metabolic alkalosis
32
Sensitization to which allergen has been most closely linked to 'thunderstorm induced asthma'?
Dust Mite
Grass Pollen
Cat
Outdoor mold spores
33
Which of the studies listed below can be used to 'predict' an ABPA recurrence (with doubling often indicating a flare)?
A. fumigates serum IgG/ precipitating Antibodies
A. fumigates serum IgE
Total serum IgE
AEC
34
Which of the following is NOT considered a risk factor for the development of asthma?
Atopy (eg a diagnosis of AD or AR)
Female gender in infancy, male gender in adults
Viral wheeze in infancy associated with rhinovirus infection
Obesity
35
This enzyme serves as the entry point into human cells for SARS-CoV-2
ACE-1
ICAM-1
Sialic acid receptor
ACE-2
36
Identify the asthma sputum finding pictured below
Curschmann’s spirals
Creola bodies
Charcot-Leyden crystals
Major Basic Protein (MBP)
37
Early sensitization to which indoor allergen listed below has been LEAST associated with asthma pathogenesis?
Dust Mite
Dog
Cat
Cockroach
38
An auto body painter is diagnosed with OA, she previously worked installing insulation. Most likely tigger?
Anhydrides
Plicatic Acid
Potassium Dichromate
Isocyanates
39
A 44 y/o male who works in a plastic and adhesive factory develops OA. Most likely tigger?
Isocyanates
Potassium Dichromate
Anhydrides
Plicatic Acid
40
A sawmill worker is diagnosed with occupational asthma after the mill begins to process Western Redwood Cedar? Trigger?
Anhydrides
Isocyanates
Plicatic Acid
Potassium Dichromate
41
Sinus dz → saddle nose deformity, lower lobe cavitary lesions/ alveolar hemorrhage, renal dz 80%, PR3-ANCA
Sarcoidosis
Microscopic polyangiitis (MPA)
Eosinophilic Granulomatosis with Polyangitis (EGPA)
Granulomatosis with Polyangiitis (GPA)
42
Patients with allergic sensitization generally experience less severe COVID infections. This may be due to:
Increased S1/S2 ratio of class I fusion protein
Decreased S1/S2 ratio of class I fusion protein
Increased ACE-2 expression
Decreased ACE-2 expression
