Antimicrobial Regimen Selection - Thompson

Question 1

What is de-esclate therapy?

Accepted Answer

Usually 2-3 days after cultures obtained, Choose narrowest spectrum therapy based on C/S, May ↑ number of drugs but still ↓ spectrum, usually going from BROAD to NARROW spectrum

Question 2

Which clinical parameters do you monitor?

Accepted Answer

All are correct - FOLLOW UP

Question 3

“Standardized” suspension of the organism is used to inoculate the agar surface

Accepted Answer

Kirby Bauer method

Question 4

What are some notable drug toxicities?

Accepted Answer

Nephrotoxicity, Neurotoxic effect, Seizures, Ototoxicity

Question 5

What are some drugs with good bioavailability - IV to PO switch

Accepted Answer

Moxifloxacin, Levofloxacin, Ciprofloxacin, Doxycycline

Question 6

What are some notable drug toxicities?

Accepted Answer

All of the above

Question 7

Lowest antimicrobial concentration that prevents visible growth of an organism after 18-24 hours of incubation

Accepted Answer

Minimum inhibitory concentration (MIC)

Question 8

concentration of antibiotic that kills 99.9% or 3-logs of the original inoculum

Accepted Answer

Minimum bactericidal concentration (MBC)

Question 9

source control may involve removal of prosthetic materials such as catheters & infected tissue or drainage of an abscess

Accepted Answer

True

Question 10

What transmissible diseases are spread from person to person?

Accepted Answer

communicable or contagious

Question 11

Uses “test cards”Inoculate wells with bacterial suspensionPhotometer measures turbidity changes over time

Accepted Answer

Automated tested

Question 12

organism is resistant to usually achievable serum drug levels

Accepted Answer

resistant

Question 13

drug concentration needed for inhibition is usually attainable, but response rates may be lower than for S isolates

Accepted Answer

intermediate

Question 14

How do you suspect infection?

Accepted Answer

Clinical presentation, Non-micorbiological lab studies, Physical findings, Patient History

Question 15

organism is inhibited by serum concentration of the drug that is achieved using recommended dosage

Accepted Answer

sensitive

Question 16

Ellipse (growth inhibition) determines MIC depending on where it intersects the stripiv) Quantitative, more expensive

Accepted Answer

E-test

Question 17

What are some host factors for selecting empiric therapy?

Accepted Answer

Comorbid conditions, Renal and hepatic function, From community or hospital, age, weight, allergies

Question 18

A summary of susceptibility patterns w/in an institution over a specific period of time - helps guide empiric therapy

Accepted Answer

Antibiogram

Question 19

What are some drugs with good bioavailability - IV to PO switch

Accepted Answer

Clindamycin, SMX-TMP, Linezolid, Metronidazole

Question 20

What are the most common reasons pt seek medical care?

Accepted Answer

infectious disease-related illnesses

Question 21

For each organism:antibiotic pair there is a particular cutoff MIC that defines susceptibility.

Accepted Answer

breakpoint

Question 22

What are the 3 primary factors that impact treatment decisions?

Accepted Answer

All are correct

Antimicrobial Regimen Selection - Thompson

Questions 22

Antimicrobial Regimen Selection - Thompson

Questions 22