Heme Test 3 MLS

Question 1

WHICH OF the following hemoglobins have an increased O2 affinity?

Accepted Answer

Hgb Chesapeake, methemoglobin

Question 2

Patients with SCD usually do not exhibit symptoms until 6 months of age because:

Accepted Answer

Higher levels of Hb F are present

Question 3

Why is Hgb solutiblty test not the definitve test for Hb s?

Accepted Answer

affected by hyperlipidermia, affected by low Hct

Question 4

Common clinical symptoms of anemia include:

Accepted Answer

Shortness of breath and fatigue

Question 5

In men and postmenopausal women whose diets are adequate, iron deficiency anemia most often results from:

Accepted Answer

Chronic gastrointestinal bleeding

Question 6

An increase in which one of the following suggests a shortened life span of RBCs and hemolytic anemia?

Accepted Answer

Reticulocyte count

Question 7

Which of the following laboratory findings is inconsistent with b-thalassemia minor?

Accepted Answer

Elevated MCHC and spherocytic RBCs

Question 8

What does this Hgb elec help you infer?

Accepted Answer

Hgb D

Question 9

Answer the following about this 1 year old Indian patient

Accepted Answer

Hb CO

Question 10

In which part of the world is the a gene mutation causing Hb Bart hydrops fetalis (– –/– –) most common?

Accepted Answer

Southeast Asia

Question 11

Answer the following about this woman in an old house

Accepted Answer

Serum lead level

Question 12

Which of the following Hb S compound heterozygote exhibits the mildest symptoms?

Accepted Answer

Hb SG

Question 13

Answer the following about this Asian baby

Accepted Answer

Iron deficiency anemia

Question 14

Select the correct iron panel for a person with ACI

Accepted Answer

d

Question 15

Which hemoglobinopathy is more common in Southeast Asian patients?

Accepted Answer

Hb E

Question 16

In the pathogenesis of the anemia of chronic inflammation, hepcidin levels:

Accepted Answer

Increase during inflammation and reduce iron absorption from enterocytes

Question 17

Which of the following is detectable only by examination of a peripheral blood film?

Accepted Answer

Poikilocytosis

Question 18

The thalassemias are caused by:

Accepted Answer

Absent or defective synthesis of a polypeptide chain in hemoglobin

Question 19

The predominant hemoglobin present in b0-thalassemia major is:

Accepted Answer

Hgb F

Question 20

answe the following about this pregant woman

Accepted Answer

The patient is in stage 2 of iron deficiency, before frank anemia develops.

Question 21

The substitution of valine for glutamic acid at position 6 of the b chain of hemoglobin results in hemoglobin that:

Accepted Answer

Polymerizes to form tactoid crystals

Question 22

Painful crises in patients with SCD occur as a result of:

Accepted Answer

Vasoocclusion

Question 23

Thalassemia is more prevalent in individuals from areas along the tropics because it confers:

Accepted Answer

Selective advantage against malaria

Question 24

Hb H inclusions in a supravital stain preparation appear as:

Accepted Answer

Small, evenly spread, greenish-blue granules that pit the surface of RBCs

Question 25

Which of the following is the most definitive test for Hb S?

Accepted Answer

Hemoglobin electrophoresis at acid pH

Question 26

In the erythropoietic porphyrias, mild anemia may be accompanied by what distinctive clinical finding?

Accepted Answer

Heightened propensity for sunburn

Question 27

an anemic adult patient with an MCV of 125 fL and an RDW of 20% can have which of the following conditions?

Accepted Answer

B12 defieicny

Question 28

When one a gene is deleted (a–/aa), a patient has:

Accepted Answer

Normal hemoglobin levels

Question 29

Heterozygous HPFH is characterized by:

Accepted Answer

10% to 35% Hb F with normal RBC morphology

Question 30

In which of the following geographic areas is Hb S most prevalent?

Accepted Answer

Sub-Saharan Africa

Question 31

What are the initial laboratory tests that are performed for the diagnosis of anemia?

Accepted Answer

CBC, reticulocyte count, and peripheral blood film examination

Question 32

DNA analysis shows a patient has the sickle mutation in both b-globin genes. Describe the genotype (two terms)

Accepted Answer

Homozygous/disease

Question 33

RBC destruction that occurs when macrophages ingest and destroy RBCs is termed:

Accepted Answer

Macrophage-mediated

Question 34

Answer the following

Accepted Answer

Insufficient erythropoiesis

Question 35

The condition Hb S-b0-thalassemia has a clinical course that resembles:

Accepted Answer

Sickle cell anemia

Question 36

Which of the following individuals is at the greatest risk for the development of anemia of chronic inflammation?

Accepted Answer

A 30-year-old man with severe rheumatoid arthritis

Question 37

Answer the following about this guy with Hogkin lymphoma

Accepted Answer

Anemia of chronic inflammation

Question 38

Which of the following patients would be considered anemic with a hemoglobin value of 14.5 g/dL?

Accepted Answer

a newborn boy

Question 39

Answer the following about this anemia old woman

Accepted Answer

Yellow skin and eyes

Question 40

parents are both heterozygous for Hb S. What percentage of their kids could have sickle cell anemia (Hb SS)?

Accepted Answer

25%

Question 41

A qualitative abnormality in hemoglobin may involve all of the following except

Accepted Answer

Decreased production of a globin chain

Question 42

Hb Bart is composed of:

Accepted Answer

Four g chains

Question 43

Answer the following about a guy with a bladder infection

Accepted Answer

The patient has Hb M.

Question 44

The term hemolytic disorder in general refers to a disorder in which there is:

Accepted Answer

Increased destruction of RBCs after they enter the bloodstream

Question 45

Unstable hemoglobins show all of the following findings EXCEPT:

Accepted Answer

Only homozygotes are symptomatic

Question 46

would condition would an anemic patient with an absolute reticulocyte count of 20 x 10^9/L and an MCV of 65 fL have?

Accepted Answer

Iron deficiency

Question 47

Sideroblastic anemias result from:

Accepted Answer

Failure to incorporate iron into protoporphyrin IX

Question 48

Megaloblastic episodes in SCD can be prevented by prophylactic administration of:

Accepted Answer

folic acid

Question 49

RBC morphologic features in b-thalassemia would most likely include:

Accepted Answer

Microcytes, hypochromia, target cells, elliptocytes, stippled cells

Question 50

b-Thalassemia minor (heterozygous) usually exhibits:

Accepted Answer

Increased Hb A2

Question 51

Which of the following aew important to consider in the patient’s history when investigating the cause of an anemia?

Accepted Answer

Diet and medications, Bleeding episodes in the patient or in his or her family members, Occupation, hobbies, and travel

Question 52

Answer the following about peripheral blood smear, see crystals

Accepted Answer

Substitution of lysine for glutamic acid at position 6 of the b chain

Question 53

Hb H is composed of:

Accepted Answer

Four b chains

Question 54

In general, the hereditary hemochromatoses result from mutations that impair:

Accepted Answer

The hepcidin-ferroportin iron regulatory system

Question 55

The hemolytic anemia associated with the thalassemias is due to:

Accepted Answer

Imbalance of globin chain synthesis

Question 56

Which one of the following is reduced as an adaptation to long-standing anemia?

Accepted Answer

Oxygen affinity of hemoglobin

Question 57

In what situation will increased levels of free erythrocyte protoporphyrin be present?

Accepted Answer

Any condition that prevents iron incorporation into protoporphyrin IX

Question 58

screening test for Hb S that uses a reducing agent, such as sodium dithionite, works b/c hemoglobins that sickle:

Accepted Answer

Are insoluble in reduced, deoxygenated form

Question 59

Which one of the following individuals is at greatest risk for the development of iron deficiency anemia?

Accepted Answer

A 15-year-old boy who eats mainly fast food and junk food

Question 60

Schistocytes, ovalocytes, and acanthocytes are examples of abnormal changes in RBC:

Accepted Answer

Shape

Heme Test 3 MLS

Questions 60

Heme Test 3 MLS

Questions 60