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Duplicate of Literature and Eval Exam 1
Duplicate of Literature and Eval Exam 1
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1
Cohort studies aime to find?
Cause
Exposures
Associations
Outcomes
2
Who controls the FAERS
DEA
CDC
FDA
PCTB
3
What does the letter O stand for in the PICO method
Obstructive
Obtain
Outcome
Observe
4
What does the letter I stand for in the PICO method
Indication
Immunization
Intervention
Insurance
5
T/F: Before a systematic search is started, it is important to define the ultimate question of Acquire
True
False
6
What are the most important characteristics of a patient
Primary problem
Co-existing
Gender, age, ethnicity
Concomitant medication
7
What does RCTs stand for
Randomized Controlled Trials
Real Hunt Treatment
Reaction Contribution Time
Race Collection Trophy
8
What does the letter C stand for in the PICO method
Comparator
Collect
Chemotherapy
Computer
9
Big Three Questions are
Were the patients adequately blinded
Were the Allocations concealed
Were the patients allowed to know some information
Is this study Randomized
10
Select some of the proper drug information specialty resources
Clinical Pharmacology
Lexicomp
Micromedex
Chicken Hub
11
Meta-anayses and RCT's are the best choice for answering which questions
Harm
Treatments
Prognosis
Diagnosis
12
We can base statistical significance off the given p-value
True
False
13
Def: A slight deviation from true ITT analysis, allows for some patients who dropped out early be excluded from analysis
Modified Intention to treat analysis
Per-protocol analysis
Intention to treat analysis
14
T/F: Subjects randomized in blocks based on certain characteristics or potential confounders is Stratified Random
True
False
15
What part of the Evaluation Tool do you find the Methods
Apply to your practice
Assessing Relevance and Validity
General Study Information
Assessing Results
16
What does a p-value of 0.05 mean
5% probability that the observed difference is actually due to type 2
50% probability that the observed difference is actually due to chance
5% probability that the observed difference is actually due to chance
50% probability that the observed difference is actually due to type 2
17
Which Data uses normal data and never crosses the number 1
Qualitative
Categorical
Numerical
Continuous
18
Separation of study enrollment from randomization in clinical trials is Allocation concealment
False
True
19
Which of the pharmaceutical resources covers lactation
Briggs
Clinical Pharmacology
Lexicomp
Micromedex
20
What is considered the Gold Standard in Hierarchy Evidence
Editorials, Expert Opinion
Cross Sectional
Randomized Controlled Trial
Cohort studies
21
Select the books that pertain to Pediatrics
Harriet Lane
Nelso
Current Diagnosis and Treatment
Briggs
22
Def: How well the study findings can be applied, extrapolated, or generalized to the population
Discussion
Internal Validity
Review
External Validity
23
T/F:
Per-protocol
and
Intention to Treat analysis
are how we account for results with dropouts from a study
False
True
24
T/F: Systemic Searching can be used to prevent cherry picking evidenc
False
True
25
What is the lowest level of Hierarchy
Case Control Studies
Case Series, Case Reports
Cross Sectional Studies
Editorials, Expert Opinion
26
Def: Only patients who completed the study are included in the final analysis
Modified intention to treat analysis
Intention to treat analysis
Per-protocol analysis
27
How does Allocation concealment work with studies
Patient has no knowlege of the next portion of the study
Allocations work with RCT
Patient has knowledge but it is limited
Allocations work with non RCT
28
T/F: The alternate wording for Methods is Materials and Methods,Patients and Methods, Study Design
True
False
29
T/F: Intervention involves recommendations
True
False
30
Which of the data base resources contains NeoFax/Pediatrics
Micromedex
Facts & Comparison
Lexi-Comp
Clinical Pharmacology
31
What are the 3 key components of Evidence based practice
Cost and Efficacy
Clinical Experience
Clinical Evidence
Patient Values
32
Which apply to Confounders
Has bigger issues in Observational studies
Circumstances that randomly cause an error in interpretation of study
Can be avoided
RCT minimize Confounding potentials
33
P-value: Tell us the probability that an observed difference in treatments is actually due to chance
False
True
34
What are considered the main alternatives or control groups for "C" Comparator of PICO method
Another drug
Standard treatment
No treatment
Untested, unapproved treatments
35
Which study allows researchers to control or alter circumstances in which the subjects are studied and evaluated
Observational
Interventional
36
T/F: Abstract is a brief summary/overview of the study, often 200-400 words
False
True
37
Which Value works hand in hand with Type 1 Errors
statistical
alpha
Null
p-value
38
Ratio Data can utilize Descriptive and Inferential statistics because it has an absolute zero
False
True
39
Which below fall under the 4 steps to clinical questions
Define
Evaluate
Apply
Search
40
Def: whether a study measured what it needed to measure, can it be trusted
Results
Internal Validity
External Validity
Discussion
41
The International Encyclopedia of Adverse Drugs is
Meyler's
Trissels
Facts & Comparison
UpToDate
42
Select which are actual color books of pharmaceutics
Purple
Green
Orange
Pink
43
Which risk score from Lexi-interact is "monitor therapy"
C
A
D
X
44
Which risk ratings from Lexi-interact is "Avoid Combination"
D
X
A
B
45
How many types of Randomization are there
2
4
3
5
46
Randomized Controlled Trials (RCT) are considered?
Platinum Standard
Bronze Standard
Gold Standard
Silver Standard
47
What does the letter P stand for in the PICO method
Pulse
Problem
Patient
Pass
48
Which study is considered backward-looking
Prospective
Retrospective
49
Efficacy differences between two interventions and provide insight regarding the compared effectiveness of the study?
Active Controlled trial
Placebo Controlled trial
50
Point Estimate: Mean difference is used by
Continuous
Categorical
51
How many types of Blindings exist for studies
7
3
4
5
52
Def: pooled analyses of data from similar studies is?
Randomized
Cohort
Meta
Case
53
Confidence intervals (CI) provides the information to tell you the direction of difference or the strength/magnitude
True
False
54
Which is considered Categorical
Blood Pressure
Mortality
DM monitoring (A1c)
No nut for 30days
55
T/F: Assessing Internal Validity is Objective?
False
True
56
What is the Highest of the Hierarchy Evidence Pyramid
Meta Analyses
Cohort Studies
Systemic Reviews
Cross Sectional Studies
57
Why is the ITT analysis more preferred?
Limited guidance
Less Chances of Difference between groups
Per-protocol analysis exaggerated effects
Conservative type of analysis
58
Which is a Type 2 Error
False Negative
False Positive
Inconclusive
Triple Negative
59
What can affect a p-value
Consistency
Size of treatment effect
Study size
Purity of treatment
60
Disproportionate number of subjects in one study group leave the study is Missing Data Bias/Withdrawal Bias
False
True
61
What are 3 of the 4 R's pertaining to systematic searching
React
Research
Receive
Record
62
T/F: Assess the prevalence of condition or event in a certain patient population at a specific point (Cross Sect)
True
False
63
Which is a Type 1 Error (chance)
Inconclusive
False Negative
Triple negative
False Positive
64
Select the types of Randomization
Simplified
Cluster
Stratified
Blocked
65
T/F: Systematic Searching helps us know when we can start searching
True
False
66
Which study allows for prospective or retrospective in nature
Observational
International
67
Which study is considered Forward-looking
Retrospective
Prospective
68
process that helps ensure subjects and/or researchers are unaware of treatment assignment is Blinding
True
False
69
Case-Control studies aim to find?
Adherence
Treatment
Cause
Risk Factors
70
Which of the 4 R's require gathering background information and categorizing the question
Receive
Research
Respond
Record
71
T/F: The PICO method is designed to be used during the Appraisal section of the 4 A's
False
True
72
Where can you find Results in an article
Apply your practice
Assessing
Relevance and Validity
General Study Information
73
Which Data is based off having No absolute Zero
Qualitative
Numerical
Categorical
Continuous
74
T/F: LactMed is a database for Drugs and Lactation for breast feeding women
True
False
75
T/F: Patients are randomized to treatment or control group within blocks of a pre-determined size = Blocked
True
False
76
p-value < 0.001 is considered?
Statistically Significant
Not Statistically Significant
Low probability of chance
High probability of chance
77
T/F: Discussions is found in the Apply to your practice
True
False
78
What are the 3 steps of Appraise
Research
Relevance
Results
Validity
79
Caveats of Hierarchy evidence pertains to
Meta analyses
Limitations
Systemic reviews
Strengths
80
Flipping a coin in a football game is considered which assessment
Bias
Confounder
Randomized (Stratified)
Randomized (Simple)
81
What are the overall risks of bias of study
Subjective
Unlimited guidance
Objective
Limited guidance
82
Type 1 Errors Erroneously Reject the Null Hypothesis
True
False
83
which are types of bias
Selection
Opinion
Systematic
Information
84
Establish efficacy of an intervention and benefit over no treatment with no comparison to other treatments?
Active Controlled trial
Placebo Controlled trial
85
Def: All patients randomized into the study are included in the final analysis
Modified intention to treat analysis
Intention to treat analysis
Per-protocol analysis
86
What are the 3 of the 4 A's of Clinical Steps questions?
Assess
Appraise
Ask
Apply
87
T/F: Bias is a circumstance in a study which are systematically introduced by researchers (nonrandom)
True
False
88
Type 2 errors – Fail to reject the null hypothesis
True
False
89
T/F: RCTs aim to test whether a certain intervention causes certain outcomes
True
False
90
What are the ultimate goals of healthcare
Improve Quantity of Life
Improve QOL
Improve the lenth of our manhood
Improve disease state outcomes
91
T/F: P- values and Type I Errors are closely related
True
False