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Pharmacology Exam 1
Pharmacology Exam 1
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1
Which drug name can help identify its classification?
Nick name
Brand name
Generic name
Chemical name
2
For a patient without a sulfa allergy, which of the following teaching points is most important for celecoxib/Celebrex?
Celecoxib can be administered with aspirin during periods of infection.
Any chest pain should be reported to the prescriber immediately.
Increased mobility should be reported to the prescriber.
Celecoxib can reduce the risk of stroke and MI.
3
What lab value will the nurse use to assess the effectiveness of filgrastim/Neupogen treatment?
Uric acit
Leukocyte count
Platelet count
Erythrocyte count
4
What alerts providers to potential severe adverse effects & brings to consumer’s attention the major risks of a drug?
Tiny writing on drug commercials
Black box warning
Fast talker on drug commercials
Red bold font in packet inserts
5
The nurse explains to the patient that an expected outcome after the administration of filgrastim/Neupogen is
Decreased infections
Decreased LDL cholesterol
Decreased bleeding
Decreased pain and inflammation
6
Don't block this information from your mind - what type of drug interacts with receptors just like natural hormones?
anarchist
antagonist
agonist
amalgamist
7
For what patient would a nurse expect to assess for an alteration in drug metabolism?
A 67-year-old woman with cirrhosis of the liver
A 50-year-old man in acute renal failure
A 47-year-old man with cirrhosis of the liver
A 35-year-old woman with cervical cancer
8
What drug is given to pt with an ischemic stroke?
Antiplatelet drugs
Direct thrombin inhibitor drugs
Anticoagulant drugs
Thrombolytic drugs
9
Which statement regarding LDL lowering cholestyramine/Questran would require additional patient teaching?
“I may need to supplement my intake of fat-soluble vitamins A, D, E, and K”
“I need to mix the powder with water or other fluids before I take it.”
“I am taking this medication to decrease my LDL cholesterol level”
“I take this drug with a full glass of water and with my other medications”
10
I am not kidding - the pain is not humerus. In addition, which lab below are seriously affected by filgrastim/Neupogen
basophils
neutrophils
hematocrit
hemoglobin
11
Which types of food would be beneficial while on taking epoetin alfa/Epogen?
Eggs or grapefruit
Low-fat dairy products or fish
Poultry or rice
Red meat or spinach
12
Generic names are often similar in the same drug class, but not always. What is always required of generic drugs?
Categorized according to overall usefulness and potential for abuse
Required to be protected by a current American patent
Created as therapeutically equivalent to brand name drugs
Designated and patented exclusively by the manufacturer
13
Colchicine reduces inflammation in gout and can cause what adverse effect that is similar to statins?
intermittent claudication
rhabdomylosis
leukocytosis
alopecia
14
A pt taking allopurinol should be educated on fluid consumption, the effects of vitamin c, eye health, and which lab?
Serum uric acid levels
Absolute neutrophil count
Liver enzymes
C-reactive protein level (CPR)
15
Pt Hgb is 12.8 g/dL. What action does this assessment finding necessitate regarding the epoetin alfa?
Holding the medication
Requesting an increase in the dose
Administering an unscheduled dose
Changing the route of administration
16
HIT can develop in heparin and require treatment with argatroban. What similar drug has a lower risk of HIT?
Clopidogrel
Alteplase
Enoxaparin
Aspirin
17
If you ad me as a reference source you learn that you kin move drugs through your body. What do drugs do to the body?
Pharmacokinetics
Pharmacotherapy
Pharmacodynamics
Pharmacogenetics
18
EGGGOS can cause a risk for bleeding. The acronym stands for
Kellogg's frozen breakfast food
Drug names
Herbal supplements
Something to LEGGO of
19
Protamine sulfate is the antidote for which drug?
Warfarin
Heparin
Argatroban
Alteplase
20
I am not lying when I ask you to identify which drug is best for reducing triglycerides?
Bile sequestrants
Statins
Fibrates
Cholesterol absorption inhibitors
21
A client has been prescribed intravenous heparin. What laboratory value is prioritized with heparin?
Platelet count
d-Dimer
PT/INR
aPTT
22
Protecting the public is the premise behind
Drug representatives
Drug commercials
Drug laws
Drug handbooks
23
I bet you don't have the heart to miss this question - what 2 organs play the biggest role in toxicity?
Heart and liver
Liver and lungs
Kidney and small intestines
Kidney and liver
24
A nurse administers celecoxib to a pt without an allergy to sulfa or aspirin to treat which health condition?
Gout
Migraine
Arthritis
Osteoporosis
25
You know this so well that it is in your blood. What factor influences drug absorption?
Pharmacodynamics
Kidney function
Liver function
Route of administration
26
The community health nurse is caring for a client with an oral chemotherapy drug. What should the nurse know?
Appropriate herbal substitutes for the chemotherapy agent
Ways to match the dose to the severity of the symptoms
Techniques for safely handling the drug
Techniques for self-monitoring of liver status
27
A pt's med is changed from IV to PO for discharge. The drug's bioavailability change will require an increase dose d/t
Passive diffusion
Glomerular filtration
First pass effect
Active transport
28
Postsurgical pt has risk for DVT. Which drug will be prescribed while in the hospital?
Vitamin K
Clopidogrel/Plavix
Cilostazol/Plental
Heparin
29
The nurse explains to a patient that aspirin suppresses blood clotting by
Dissolving existing clots
Inhibiting clotting factors
Inhibiting platelet aggregation
Inhibiting production of red blood cells
30
A client has chronic renal failure with SOB from anemia. The nurse would anticipate which medication order?
Penicillin
Epoetin alfa/Epogen
Filgrastim/Neupogen
Interferon alpha 2b
31
Myopathies are a serious adverse reaction in statins. We need to watch for
Decreased range of motion
Muscle pain
Joint pain
Excess salivation
32
A patient with hepatitis can have abnormalities in which phase of pharmacokinetics that involves CYP enzymes?
Metabolism
Absorption
Excretion
Distribution
33
Vitamin K is the antidote for which drug?
Warfarin
Heparin
Alteplase
Argatroban
34
Although you can't take this drug with grapefruit juice, the best drug for dyslipidemia is
atorvastatin/Lipitor
cholestyramine/Questran
fenofibrate/TriCor
alirocumab/Praluent
35
Kids can't take aspirin d/t Reye's but adults can. Which of the following is important patient education
take the medication 2 hours after a meal to enhance absorption
take the medication after a meal to prevent gastric irritation
crush the enteric-coated tablet for increased effectiveness
take the medication on an empty stomach to enhance absorption
36
I had my gallbladder removed in college. Before surgery, which drug to lower my LDLs would have been contraindicated?
fenofibrate/TriCor
artovastatin/Lipitor
ezetimibe/Zetia
alirocumab/Praluent
37
What effect will cholestyramine/Questran have on other dyslipidemic drugs when taken at the same time?
Increased first-pass effect
Decreased absorption
Increased metabolism
Faster excretion
38
Cytotoxic drugs disrupt the cell cycle & have safety concerns. Why is pregnancy prevention needed for months after tx?
carcinogenic effect
financial cost of treatment
decreased egg production
teratogenic effect
39
clopidogrel/Plavix has which desired effect?
Removed plaque from teeth
Inhibit clotting factors
Dissolves clots
Inhibit platelet aggregation
40
Dosage form is a major determinant of which drug characteristic?
Minimum effective concentration
Bioavailability
Protein-binding capacity
Water-soluble metabolites
41
Sodium bicarbonate is the antidote for
aspirin
meloxicam
acetaminophen
celecoxib
42
All medications undergo rigorous scientific testing controlled by what organization?
The Joint Commission
Centers for Disease Control and Prevention (CDC)
Drug Enforcement Agency (DEA)
Food and Drug Administration (FDA)
43
What concern is prioritized when an adult client deliberately overdosed on acetaminophen/Tylenol?
Seizures
Acute GI bleed
Constipation
Liver failure
44
Impaired erythropoiesis is most likely to exhibit signs and symptoms associated with what health problem?
Neutropenia
DVT
Anemia
Sepsis
45
Which act requires gender-related effectiveness & safety info in the initial FDA application?
The Federal Food, Drug, and Cosmetic Act
The Controlled Drugs and Substance Act
The Food and Drugs Act
The National Institutes of Health (NIH) Revitalization Act
46
True or false: Anticoagulants prevent the formation of clots and break up current clots.
False
True
47
What agency is responsible for approving drugs for OTC availability?
The Drug Enforcement Administration (DEA)
The Food and Drug Administration (FDA)
The American Hospital Formulary Service
The National Institutes of Health (NIH)
48
What action can the nurse take to ensure that the client’s drug levels are therapeutic but not toxic?
Considering client's pharmacogenetics
Assessing client for adverse effects
Drawing drug serum level
Calculating drug half-life
49
The Drug Enforcement Agency
sets standards of drug manufacturing plants
enforces the Controlled Substance Act
regulates OTC medication approval
issues patents once a drug is FDA approved
50
Pt is on heparin. aPTT= 42 [control(30-40) therapeutic(45-70)] and INR= 2 [control(.9-1.2) therapeutic(2-3)]. You should
Hold the dose as the aPTT is too high
Notify the provider that the aPTT is too low and expect a dose increase
Hold the dose as the INR is too high
Administer the next dose as ordered as labs are OK
51
A reaction to ibuprofen can lead to loss of sight, and scarring and can be fatal is SJS. What else can occur in SJS?
Skin and mucous membranes blistering
Kidney failure
Loss of thermoregulation
Dysmennorhea
52
Which characteristic allows for a drug to be stored in the body and released as needed?
Having a rapid rate of metabolism
Having a long half-life
Being protein bound
Being lipid soluble
53
To treat an acetaminophen/Tylenol overdose, we would administer which of the following?
sodium bicarbonate
protamine sulfate
acetylcysteine
argatroban
54
PTT [control(30-40) therapeutic(45-70)] INR [control(.9-1.2) therapeutic (2-3)]. When would you hold warfarin?
PTT is 75 seconds
PTT is 25 seconds
INR is 0.8
INR is 6
55
Which type of drug has the lowest risk of allergic reactions?
Recreational
Semi-synthetic
Natural
Synthetic
56
True or False: Hand washing is the most important measure for health care workers to take around cytotoxic drugs.
False
True
57
Pt is on cilostazol for intermittent claudication, where would we watch for signs of cramping?
Heart
Legs
Arms
Brain
58
Although US citizens don't get free universal healthcare coverage, how many Medication Rights are there?
13.4275
7
10
1
59
Which drug can be administered to a client with a high risk for bleeding?
Acetaminophen/Tylenol
Ibuprofen/Advil
Indomethacin/Indocin
Aspirin/Ecotrin
60
The expected outcome of administering epoetin alfa/Epogen to a patient with chronic kidney disease is
Decrease bleeding
Decrease infections
Increase red blood cell production
Increase white blood production