Quiz 3 Antimicrobials

Which of the following is a potential side effect of long-term Linezolid therapy?

Which of the following is an institutional variable that can influence the risk of Surgical Site Infection?

What is the intrinsic antimicrobial activity of beta-lactamase inhibitors like Clavulanic acid, Sulbactam & Tazobactam?

How does Linezolid inhibit bacterial protein synthesis?

When should Azithromycin be administered to optimize its bioavailability?

Which class of antimicrobials requires dose adjustment in patients with renal impairment?

Which med causes pre & post neurojunctional effects, potentially prolonging neuromuscular blockade?

An uninfected operative wound with no inflammation, no viscus entered & is closed primarily is classified as clean

Which of the following antibiotics is considered safe for use in pregnancy?

Why is anesthesia the discipline responsible for administering prophylactic ABX prior to surgical incision? 

Aztreonam is unique among beta-lactam antimicrobials for its highly selective activity against which type of bacteria?

 Amoxicillin is very similar to Ampicillin but differs in which significant aspects?

Which factor can make antimicrobial therapy less effective at the site of infection?

A pt tanking Aminoglycosides has tinnitus, a feeling of ear pressure/fullness & sudden hearing loss. These are S&S of...

D/t its rapid renal excretion, the plasma concentration of PCN G decreases by _______ w/n the 1st hr after the 1st dose.

For which surgical procedure is Cefazolin + Metronidazole the preferred prophylactic antibiotic regimen?

A pt receiving a high dose of IV PCN G for a severe infection with renal dysfunction, is at risk for which ADR?

Vancomycin is the drug of choice for...

Which of the following conditions is a known indication for prophylaxis with Penicillin G?

For Neurosurgery, what is the preferred prophylactic antimicrobial agent?

Due to its absorption characteristics, Carbenicillin must be administered via which route?

Within what timeframe prior to surgical incision should prophylactic antibiotics generally be administered?

What physiological effect of perioperative hypothermia can increase the risk of surgical site infection?

Skeletal muscle weakness is a SE of aminoglycosides. Which intervention can treat this specific effect?

For a 90 kg pt, what is the dose of Vancomycin for surgical prophylaxis & how long prior to incision should it be given?

For an initial episode of non-severe Clostridium difficile infection, Metronidazole may be used if...

Which of the following meds is contraindicated during pregnancy due to potential fetal toxicity, such as arthropathies?

Which of the following is NOT a risk factor for Surgical Site Infections?

Carbenicillin, a 3rd gen PCN, is associated with which significant side effect, especially in patients with CHF?

According to the Surgical Wound Classification, a "Contaminated" wound is characterized by...

 What is the recommended dose of Vancomycin for a patient weighing less than 80 kg?

Administering high-dose PCN G intrathecally is contraindicated d/t the risk of which severe neurological complications?

What is the most common site for nosocomial infections?

Azithromycin's dosing regimen is often a 5 day course (500mg Day 1, 250mg Days 2-5). This is primarily due to its...

For a patient undergoing a Liver Transplant, what is the preferred antimicrobial agent for prophylaxis? 

Which class of penicillins is specifically indicated for Staph infections that produce beta-lactamase enzymes?

Which of the following Cephalosporins is the only second-generation drug effective against meningitis?

A pt with a IgE-mediated anaphylactic reaction to PCN requires surgical prophylaxis. Which alt med is preferred?

A 130 kg pt requires a prophylactic dose of Cefazolin. What is the rec dose and re-dosing interval for Cefazolin?

When used w/ neuraxial analgesia, Chlorhexidine can cause neurotoxicity if it enters the CSF. What caution is advised?

Which of the following surgical procedures is listed as generally NOT requiring prophylactic antibiotics?

A sig. SE of Fluoroquinolones, particularly in pts > 60 yrs old, on corticosteroids, or transplant recipients, is...

In addition to tendon inflammation & rupture, Fluoroquinolones carry a risk of exacerbating weakness in patients with...

For Orthopedic Surgery, if a patient has a beta-lactam allergy, what is the recommended alternative prophylactic agent?

Prophylactic antibiotics should generally be discontinued within what timeframe after surgery end time?

Which of the following statements about the elimination of Aminoglycosides is TRUE?

Which of the following cephalosporins are known to penetrate the CSF, making them suitable for treating meningitis?

Which of the following accurately describes the mechanism of action for Penicillins?

Which of the following aminoglycosides is known to be primarily cochleotoxic?

Why do pregnant patients often experience decreased plasma concentrations of antibiotics administered orally?

What is the primary effect of administering Probenecid concurrently with Penicillins?

Moxifloxacin has several severe SEs & should not be used unless less toxic options aren't available. What is an ex?

Which PCNase-resistant PCN is excreted in bile & can be used to treat staph. meningitis d/t its CNS penetration?

What is a common characteristic of first-generation cephalosporins like Cefazolin?

A pt receiving an aminoglycoside develops muscle weakness. What mechanism of aminoglycosides causes this side effect?

Which statement is TRUE regarding Cephalosporins?

Which type of PCN allergy reaction is not considered a true IgE-mediated reaction but rather d/t chemical impurities?

Which 2 ABX are exceptions to the "within 1 hour prior to surgical incision" rule & can be given within 2 hours instead?

Erythromycin is metabolized by? What is the potential cardiac risk associated with increased plasma levels?

Compared to other PCNs, 4th-gen acylaminopenicillins (Mezlocillin, Azlocillin, & Piperacillin) are notable for their...

Bacteria can develop resistance to cephalosporins by producing which specific enzymes?

Which of the following is a known side effect of Methicillin?

If a pt undergoes Colorectal or appendectomy surgery w/ a beta-lactam allergy, which med is recommended for prophylaxis?

The combination of Piperacillin with Tazobactam (Zosyn) is effective because Tazobactam...

Despite its advantages, a significant disadvantage of Aztreonam is its potential to cause...

When is redosing of a short-acting prophylactic ABX like Cefazolin or Piperacillin-Tazobactam gen rec during surgery?

Rapid IV infusion of Vancomycin (< 30 minutes) is most commonly associated with which significant adverse effect?

What 3rd gen cephalosporin has the longest 1/2 life & is effective against Gram - bacilli like Neisseria & Haemophilus?

What feature in 4th-gen cephalosporins like Cefepime is diff from earlier gens, leading to enhanced Gram - activity?

Which statement accurately describes the effectiveness of Cephalosporins across their generations? 

Which antimicrobial is most notably associated with causing severe pseudomembranous colitis?